Evidence map›Paper›PMID 34064762›Full record

ArticleNutrients2021

Administration of

Guangsu Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Nutrients · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Isoquinoline alkaloids inChinese herbal medicines · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Regulating the crosstalk betweenFrontiers in immunology · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guangsu ZhuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Gang WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-2007-2143
Jiangnan University · CN

Funding

Fundamental Research Funds for the Central Universities JUSRP22006Fundamental Research Funds for the Central Universities JUSRP51501national first-class discipline program of Food Science and Technology JUFSTR20180102National Natural Science Foundation of China 31820103010National Natural Science Foundation of China 31972052National Natural Science Foundation of China 32021005
6 · The paper itself

Abstract

Psychobiotics are used to treat neurological disorders, including mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the mechanisms underlying their neuroprotective effects remain unclear. Herein, we report that the administration of bifidobacteria in an AD mouse model improved behavioral abnormalities and modulated gut dysbiosis.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBifidobacterium breveBrainBrain-Derived Neurotrophic FactorCognitionCognitive DysfunctionDisease Models, AnimalDysbiosisFibronectinsGastrointestinal MicrobiomeMiceNeuronal PlasticityPeptide FragmentsProbioticsAmyloid beta-Peptidesamyloid beta-protein (1-42)Bdnf protein, mouseBrain-Derived Neurotrophic FactorFibronectinsFNDC5 protein, mousePeptide FragmentsAlzheimer’s diseaseBifidobacteriumcognitive impairmentgut-brain axismicrobiota

Identifiers

PMID34064762
PMCPMC8150793
OpenAlexW3160902918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.