Evidence map›Paper›PMID 34064550›Full record

ReviewMarine drugs2021

Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome.

Tamara Rubilar, Elena S Barbieri, Ayelén Gazquez, Marisa Avaro

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05531019 (COVID-19 Sequelae), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05531019 nacompletednot on this map

COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochroma A.

TypeinterventionalSponsorFernando SaldariniRan2021 to 2022Enrolled54ConditionsLong COVIDArmsEchinochrome A, Control
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Echinochrome A inhibits HMGB1-induced vascular smooth muscle cell migration by suppressing osteopontin expression.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tamara RubilarLaboratorio de Química de Organismos Marinos, Instituto Patagónico del Mar, Universidad Nacional de la Patagonia San Juan Bosco (UNPSJB), Puerto Madryn 9120, Chubut, Argentina.
Elena S BarbieriLaboratorio de Oceanografía Biológica, Centro Para el Estudio de Sistemas Marinos (CESIMAR), CONICET, Puerto Madryn 9120, Chubut, Argentina.ORCID 0000-0003-4860-3954
Ayelén GazquezInstituto Tecnológico de Chascomús, The Chascomús Technological Institute (INTECH), CONICET-UNSAM, Chascomús 7130, Buenos Aires, Argentina.
Marisa AvaroLaboratorio de Química de Organismos Marinos, Instituto Patagónico del Mar, Universidad Nacional de la Patagonia San Juan Bosco (UNPSJB), Puerto Madryn 9120, Chubut, Argentina.
National University of Patagonia San Juan Bosco · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCytokine Release SyndromeHumansImmunityNaphthoquinonesOxidation-ReductionPigments, BiologicalReactive Oxygen SpeciesSea Urchinsechinochrome ANaphthoquinonesPigments, BiologicalReactive Oxygen Speciescytokine storm syndromenatural productspigmentssea urchinspinochromes

Identifiers

PMID34064550
PMCPMC8151293
OpenAlexW3162134210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.