ArticleMolecules (Basel, Switzerland)2021
Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sensitive Methanol and Formaldehyde Detection in Enzyme Assays Shows Applicability to Diverse Sample Matrices.ACS omega · 2026Article
- Chalcone Derivatives: Antioxidant Activity, Photoprotective Properties, and Stability under UV Irradiation.ACS omega · 2025Article
- Relaxation Dynamics in Dihydroxychalcones: Insights from Ultrafast Spectroscopy and Quantum Computations.ACS physical chemistry Au · 2025Article
- Development and validation of a UV-Vis spectrophotometric method for estimation of total content of chalcone.MethodsX · 2025Article
- Synthesis, Characterization, and Docking Studies of Some New Chalcone Derivatives to Alleviate Skin Damage Due to UV Light.Molecules (Basel, Switzerland) · 2025Article
- Synthesis and Biochemical Evaluation of Ethanoanthracenes and Related Compounds: Antiproliferative and Pro-Apoptotic Effects in Chronic Lymphocytic Leukemia (CLL).Pharmaceuticals (Basel, Switzerland) · 2024Article
- Direct synthesis, characterization,Royal Society open science · 2024Article
- Unveiling the ion sensing capabailities of 'click' derived chalcone-tailored 1,2,3-triazolic isomers for Pb(ii) and Cu(ii) ions: DFT analysis.RSC advances · 2024Article
- Nephroprotective Activity ofDrug design, development and therapy · 2024Article
- The effects of UV filters on health and the environment.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Review
- Curcumin Chalcone Derivatives Database (CCDD): a Python framework for natural compound derivatives database.PeerJ · 2023Article
- Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones.International journal of molecular sciences · 2022Review
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Authors and funding
4 authors.
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Abstract
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region. Therefore, in the present work, we synthesized eight chalcone derivatives through Claisen-Schmidt condensation at room temperature. The evaluation of the optical properties of each chalcone derivatives in the UV region was conducted through spectroscopic and computational studies. The synthesized chalcones were obtained in good yields and they were active in the UV region. The results revealed that more methoxy substituents to chalcone leads toward red shift. All chalcone derivatives have high molar absorptivity value (21,000-56,000) demonstrating that they have the potential to be used as the sunscreen agent. The cytotoxicity assay showed that chalcone derivatives were demonstrating low toxicity toward normal human fibroblast cell, which is remarkable. Therefore, we concluded that the synthesized chalcones in this work were potential to be developed as novel sunscreen agents in real application.
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