ArticleCancers2021
5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)-Experience at Two Specialized Centers.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Review
- Predicting intraoperative 5-ALA-induced tumor fluorescence via MRI and deep learning in gliomas with radiographic lower-grade characteristics.Journal of neuro-oncology · 2025Article
- Double fluorescence-guided surgery with 5-ALA and fluorescein sodium in grade 2 and grade 3 adult-type diffuse gliomas: retrospective analysis of 112 cases.Brain & spine · 2025Article
- Review of Clinically Assessed Molecular Fluorophores for Intraoperative Image Guided Surgery.Molecules (Basel, Switzerland) · 2024Review
- Review
- Clinical application of intraoperative ultrasound superb microvascular imaging in brain tumors resections: contributing to the achievement of total tumoral resection.BMC medical imaging · 2024Article
- Multimodality Structural and Functional Monitoring in Brain Tumor Surgery: The Role of IONM and IOUS.Advances and technical standards in neurosurgery · 2024Review
- How Reliable Is Fluorescence-Guided Surgery in Low-Grade Gliomas? A Systematic Review Concerning Different Fluorophores.Cancers · 2023Review
- 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy.Bioengineering (Basel, Switzerland) · 2023Review
- Advances in the intraoperative delineation of malignant glioma margin.Frontiers in oncology · 2023Review
- Turning on the light for brain tumor surgery: A 5-aminolevulinic acid story.Neuro-oncology · 2022Review
- Specular Reflection Suppression through the Adjustment of Linear Polarization for Tumor Diagnosis Using Fluorescein Sodium.Sensors (Basel, Switzerland) · 2022Article
- Reduction of Specular Reflection Based on Linear Polarization Control for Fluorescence-Induced Diagnostic Evaluation.Diagnostics (Basel, Switzerland) · 2022Article
- The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers.Frontiers in molecular neuroscience · 2022Article
- Situating Sub-Saharan Africa Within Intra-Operative Innovations in Neurooncology.Frontiers in surgery · 2022Article
- 5-ALA fluorescence in indeterminate grade gliomas.Neurosurgical focus: Video · 2022Article
- 5-ALA-guided tumor resection during awake speech mapping in gliomas located in eloquent speech areas: Single-center experience.Frontiers in oncology · 2022Article
- Article
- Article
- Evaluation of a Novel Three-Dimensional Robotic Digital Microscope (Aeos) in Neurosurgery.Cancers · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The prediction of the individual prognosis of low-grade glioma (LGG) patients is limited in routine clinical practice. Nowadays, 5-aminolevulinic acid (5-ALA) fluorescence is primarily applied for improved intraoperative visualization of high-grade gliomas. However, visible fluorescence is also observed in rare cases despite LGG histopathology and might be an indicator for aggressive tumor behavior. The aim of this study was thus to investigate the value of intraoperative 5-ALA fluorescence for prognosis in LGG patients. We performed a retrospective analysis of patients with newly diagnosed histopathologically confirmed LGG and preoperative 5-ALA administration at two independent specialized centers. In this cohort, we correlated the visible intraoperative fluorescence status with progression-free survival (PFS), malignant transformation-free survival (MTFS) and overall survival (OS). Altogether, visible fluorescence was detected in 7 (12%) of 59 included patients in focal intratumoral areas. At a mean follow-up time of 5.3 ± 2.9 years, patients with fluorescing LGG had significantly shorter PFS (2.3 ± 0.7 vs. 5.0 ± 0.4 years;
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