Evidence map›Paper›PMID 34064122›Full record

ArticleInternational journal of molecular sciences2021

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant

Rareş-Petru Moldovan, Daniel Gündel, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Steffen Fischer, Magali Toussaint, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Winnie Deuther-Conrad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Development of Fluorescent 4-[4-(3Journal of medicinal chemistry · 2023
    Article
  5. Radiosynthesis and Preclinical Evaluation of anPharmaceuticals (Basel, Switzerland) · 2022
    Article
  6. Screening of σJournal of medicinal chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rareş-Petru MoldovanDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0003-3119-7945
Daniel GündelDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0001-9743-2325
Rodrigo TeodoroDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0002-1425-0567
Friedrich-Alexander LudwigDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0002-4358-5171
Steffen FischerDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Magali ToussaintDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0002-1136-3857
Dirk SchepmannInstitut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU), Corrensstraße 48, 48149 Münster, Germany.
Bernhard WünschInstitut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU), Corrensstraße 48, 48149 Münster, Germany.ORCID 0000-0002-9030-8417
Peter BrustDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0001-5555-7058
Winnie Deuther-ConradDepartment of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0003-3168-3062
Helmholtz-Zentrum Dresden-Rossendorf · DEUniversity of Münster · DE

Funding

Deutsche Forschungsgemeinschaft BR 1360/13-1
6 · The paper itself

Abstract

The σ

Indexed as

AnimalsBrainFemaleFluorine RadioisotopesHumansLigandsMaleMiceNeoplasmsRadiopharmaceuticalsRatsRats, Inbred F344Receptors, sigmaTetrahydroisoquinolines1,2,3,4-tetrahydroisoquinolineFluorine-18Fluorine RadioisotopesLigandsRadiopharmaceuticalsReceptors, sigmasigma-2 receptorTetrahydroisoquinolinesazaindolesbinding affinitybrain-penetrationF98fluorine-18 labelingglioblastomagliomaorthotopicpositron emission tomography (PET)radiochemistryrat modeltransmembrane protein 97σ2 receptor

Identifiers

PMID34064122
PMCPMC8196714
OpenAlexW3161476963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.