ReviewNutrients2021
Vitamin D: Current Challenges between the Laboratory and Clinical Practice.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Investigating the Inflammatory Link Between Vitamin D and Hidradenitis Suppurativa: A Systematic Review and Causal Inference Analysis.International journal of molecular sciences · 2026Pooled it
- Shift Work and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Vitamin D in Photosynthetic Organisms and Fungi: Sterol Photochemistry, UV-B Availability, and Biofortification Potential.Current issues in molecular biology · 2026Review
- Harnessing natural sunlight indoors: sensor-regulated therapeutic approach to enhance vitamin D status in humans.Scientific reports · 2026Article
- Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder.Diseases (Basel, Switzerland) · 2026Article
- Dummy Templated Receptors Showing Enhanced Affinity for Vitamin D3.Molecules (Basel, Switzerland) · 2025Article
- Validating cephalometric angular reconstruction for determining vertical dimension in edentulous patients.BMC oral health · 2025Article
- Seasonal and Environmental Determinants of Maternal and Neonatal Vitamin D Status: A Cross-Sectional Observational Cohort Study in Urban Greece.Healthcare (Basel, Switzerland) · 2025Article
- The Role of Vitamin D and Vitamin D Receptor in Sepsis.Current issues in molecular biology · 2025Review
- Interrelations of Leptin and Interleukin-6 in Vitamin D Deficient and Overweight Orthodox Nuns from Northern Greece: A Pilot Study.Nutrients · 2025Article
- Global Trends in Vitamin D Research From 1985 to 2024.PRiMER (Leawood, Kan.) · 2025Article
- The Role and Clinical Significance of Vitamin D in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Review
- Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency: Findings from the SarcoPhAge Cohort.Nutrients · 2024Article
- Review
- Hypovitaminosis D in university workers in Southern Ecuador: interactions between gender and lifestyle.Frontiers in nutrition · 2024Article
- The Sunlight-Vitamin D Connection: Implications for Patient Outcomes in the Surgical Intensive Care Unit.Cureus · 2023Review
- [Applying Serum Vitamin D Metabolites in the Assessment of Renal Impairment in Diabetic Kidney Disease of Type 2 Diabetes Mellitus Patients: A Retrospective Study].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- Quality Control of the Dietary Supplements Containing Selected Fat-Soluble Vitamins D and K.Nutrients · 2023Article
- Vitamin D Measurement: Clinical Practice and Research Implications.The journal for nurse practitioners : JNP · 2023Article
- An Epidemiological Investigation to evaluate the link between hypovitaminosis D and COVID-19.Journal of family medicine and primary care · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin D is a micronutrient with pleiotropic effects in humans. Due to sedentary lifestyles and increasing time spent indoors, a growing body of research is revealing that vitamin D deficiency is a global problem. Despite the routine measurement of vitamin D in clinical laboratories and many years of efforts, methods of vitamin D analysis have yet to be standardized and are burdened with significant difficulties. This review summarizes several key analytical and clinical challenges that accompany the current methods for measuring vitamin D. According to an external quality assessment, methods and laboratories still produce a high degree of variability. Structurally similar metabolites are a source of significant interference. Furthermore, there is still no consensus on the normal values of vitamin D in a healthy population. These and other problems discussed herein can be a source of inconsistency in the results of research studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.