Evidence map›Paper›PMID 34064030›Full record

ArticleJournal of personalized medicine2021

Acceptability of Pharmacogenetic Testing among French Psychiatrists, a National Survey.

Benjamin Laplace, Benjamin Calvet, Aurelie Lacroix, Stephane Mouchabac, Nicolas Picard, Murielle Girard, Eric Charles

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Pharmacogenetic Testing Knowledge and Attitudes among Pediatric Psychiatrists and Pediatricians in Alberta, Canada.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin LaplaceEsquirol Hospital Center, Department of Research and Innovation, 87000 Limoges, France.ORCID 0000-0003-2347-3735
Benjamin CalvetEsquirol Hospital Center, Department of Research and Innovation, 87000 Limoges, France.
Aurelie LacroixEsquirol Hospital Center, Department of Research and Innovation, 87000 Limoges, France.
Stephane MouchabacSaint-Antoine Hospital Center APHP, Department of Psychiatry, Sorbonne University, 75012 Paris, France.
Nicolas PicardLimoges University Hospital Center, Department of Pharmacology, Toxicology and Pharmacovigilance, 2 Avenue Martin-Luther-King, 87042 Limoges, France.
Murielle GirardEsquirol Hospital Center, Department of Research and Innovation, 87000 Limoges, France.
Eric CharlesEsquirol Hospital Center, Department of Adult Psychiatry, 87000 Limoges, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychiatric disorder management is based on the prescription of psychotropic drugs. Response to them remains often insufficient and varies from one patient to another. Pharmacogenetics explain part of this variability. Pharmacogenetic testing is likely to optimize the choice of treatment and thus improve patients' care, even if concerns and limitations persist. This practice of personalized medicine is not very widespread in France. We conducted a national survey to evaluate the acceptability of this tool by psychiatrists and psychiatry residents in France, and to identify factors associated with acceptability and previous use. The analysis included 397 observations. The mean acceptability score was 10.70, on a scale from 4 to 16. Overall acceptability score was considered as low for 3.0% of responders, intermediate for 80.1% and high for 16.9%. After regression, the remaining factors influencing acceptability independently of the others were prescription and training history and theoretical approach. The attitude of our population seems to be rather favorable, however, obvious deficiencies have emerged regarding perceived skills and received training. Concerns about the cost and delays of tests results also emerged. According to our survey, one of the keys to overcoming the barriers encountered in the integration of pharmacogenetics seems to be the improvement of training and the provision of information to practitioners.

Indexed as

acceptabilityFrancepharmacogeneticspsychiatrysurvey

Identifiers

PMID34064030
PMCPMC8223981

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.