Evidence map›Paper›PMID 34063983›Full record

ArticleCancers2021

Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma.

Thilo Gambichler, Nessr Abu Rached, Andrea Tannapfel, Jürgen C Becker, Markus Vogt, Marina Skrygan, Ulrike Wieland, Steffi Silling, Laura Susok, Markus Stücker and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Protein expression of prognostic genes in primary melanoma and benign nevi.Journal of cancer research and clinical oncology · 2022
    Article
  8. Article
  9. Article
  10. Detection ofJournal of oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Thilo GambichlerSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.
Nessr Abu RachedSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.ORCID 0000-0001-6853-0743
Andrea TannapfelInstitute of Pathology, Ruhr-University Bochum, 44789 Bochum, Germany.
Jürgen C BeckerTranslational Skin Cancer Research, German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Department of Dermatology, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0001-9183-653X
Markus VogtInstitute of Pathology, Ruhr-University Bochum, 44789 Bochum, Germany.ORCID 0000-0002-3957-5587
Marina SkryganSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.
Ulrike WielandNational Reference Center for Papilloma- and Polyomaviruses, Institute of Virology, University of Cologne, 50935 Cologne, Germany.
Steffi SillingNational Reference Center for Papilloma- and Polyomaviruses, Institute of Virology, University of Cologne, 50935 Cologne, Germany.ORCID 0000-0002-9555-3876
Laura SusokSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.
Markus StückerSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.
Thomas MeyerSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.
Eggert StockflethSkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.
Klaus JunkerDepartment of Pathology, Klinikum Bremen-Mitte, 28205 Bremen, Germany.
Heiko U KäfferleinInstitute for Prevention and Occupational Medicine of the German Social Accident Insurances (IPA), Ruhr-University Bochum, 44789 Bochum, Germany.ORCID 0000-0001-5150-4979
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurances (IPA), Ruhr-University Bochum, 44789 Bochum, Germany.
Kerstin LangInstitute for Prevention and Occupational Medicine of the German Social Accident Insurances (IPA), Ruhr-University Bochum, 44789 Bochum, Germany.
Ruhr University Bochum · DEInstitute for Prevention and Occupational Medicine · DEUniversity of Cologne · DEGerman Cancer Research Center · DEKlinikum Bremen-Mitte · DE

Funding

FoRUM research grant of the Ruhr-University Bochum F855N2-2015National Reference Center for Papilloma- and Polyomaviruses 1369-401
6 · The paper itself

Abstract

We aimed to assess for the first time the mismatch repair (MMR) protein expression in Merkel cell carcinoma (MCC). Immunohistochemistry was performed for MLH1, MSH2, MSH6, and PMS2 on patients' tumor tissue (

Indexed as

immune checkpoint inhibitorsimmunotherapyMerkel cell carcinomaMerkel cell polyomavirusmicrosatellite instabilitymismatch repair deficiency

Identifiers

PMID34063983
PMCPMC8196722
OpenAlexW3164075414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.