Evidence map›Paper›PMID 34063939›Full record

ArticleMolecules (Basel, Switzerland)2021

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I.

Chonny Herrera-Acevedo, Areli Flores-Gaspar, Luciana Scotti, Francisco Jaime Bezerra Mendonça-Junior, Marcus Tullius Scotti, Ericsson Coy-Barrera

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Chemical Modification ofInternational journal of molecular sciences · 2025
    Article
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  4. Review
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  6. Article
  7. Anti-Parasitology · 2023
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chonny Herrera-AcevedoPost-Graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-6220-9091
Areli Flores-GasparDepartamento de Química, Facultad de Ciencias Básicas y Aplicadas, Universidad Militar Nueva Granada, Cajicá 250247, Colombia.ORCID 0000-0003-2173-8007
Luciana ScottiPost-Graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-1866-4107
Francisco Jaime Bezerra Mendonça-JuniorLaboratory of Synthesis and Drug Delivery, State University of Paraíba, João Pessoa 58071-160, PB, Brazil.ORCID 0000-0003-3588-833X
Marcus Tullius ScottiPost-Graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-4863-8057
Ericsson Coy-BarreraBioorganic Chemistry Laboratory, Facultad de Ciencias Básicas y Aplicadas, Universidad Militar Nueva Granada, Cajicá 250247, Colombia.ORCID 0000-0002-3553-9749
Universidade Federal da Paraíba · BRMilitary University Nueva Granada · COUniversidade Estadual da Paraíba · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309648/2019-0, and 431254/2018-4, 308590/2017-1, 421254/2018-1 and 306798/2020-4.Vicerrectoría de Investigaciones at Universidad Militar Nueva Granada INV-CIAS-2536, 2018
6 · The paper itself

Abstract

The current treatments against

Indexed as

Antiprotozoal AgentsCarbon-13 Magnetic Resonance SpectroscopyDiterpenes, KauraneEnzyme InhibitorsInhibitory Concentration 50LeishmaniaMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureOxidoreductasesProton Magnetic Resonance SpectroscopySpectrometry, Mass, Electrospray IonizationAntiprotozoal AgentsDiterpenes, KauraneEnzyme InhibitorsOxidoreductasespteridine reductaseAsteraceaekauranesLeishmaniamachine learningmolecular dockingnatural productsvirtual screening

Identifiers

PMID34063939
PMCPMC8196580
OpenAlexW3163177237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.