ReviewJournal of clinical medicine2021
From Desire to Dread-A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Ketone Supplementation Attenuates Prediction Error Taste Response in Eating Disorders: A Proof-of-Concept Study.The International journal of eating disorders · 2026Trial
- A Survey of Canadian Psychiatrists' Attitudes Towards Palliative Care Approaches for Severe and Persistent Mental Illness: Enquête sur les attitudes des psychiatres canadiens à l'égard des approches de soins palliatifs pour les troubles mentaux graves et persistants.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026Article
- Corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis modulate avoidance behaviors and feeding.Frontiers in neuroscience · 2026Article
- Examining the biological causes of eating disorders to inform treatment strategies.Nature reviews. Neuroscience · 2025Review
- Addressing Altered Anticipation as a Transdiagnostic Target Through Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Computational Perspectives on Cognition in Anorexia Nervosa: A Systematic Review.Computational psychiatry (Cambridge, Mass.) · 2025Review
- A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa.The International journal of eating disorders · 2024Review
- What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research.Neuroscience applied · 2024Review
- Systematic review of prospective studies assessing risk factors to predict anorexia nervosa onset.Journal of eating disorders · 2023Review
- What's New in Research during the Current Epidemic Wave of Eating Disorders?Journal of clinical medicine · 2023Article
- Trait anxiety is associated with amygdala expectation and caloric taste receipt response across eating disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Brain reward response in adolescents and young adults with anorexia nervosa is moderated by changes in body weight and sweetness perception.The International journal of eating disorders · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Anorexia nervosa is a severe psychiatric illness associated with food avoidance. Animal models from Berridge et al. over the past decade showed that environmental ambience, pleasant or fear inducing, can trigger either appetitive (desire) or avoidance (dread) behaviors in animals via frontal cortex, nucleus accumbens dopamine D1 and D2 receptors, and hypothalamus. Those mechanisms could be relevant for understanding anorexia nervosa. However, models that translate animal research to explain the psychopathology of anorexia nervosa are sparse. This article reviews animal and human research to find evidence for whether this model can explain food avoidance behaviors in anorexia nervosa. Research on anorexia nervosa suggests fear conditioning to food, activation of the corticostriatal brain circuitry, sensitization of ventral striatal dopamine response, and alterations in hypothalamic function. The results support the applicability of the animal neurocircuitry derived model and provide directions to further study the pathophysiology that underlies anorexia nervosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.