Evidence map›Paper›PMID 34063857›Full record

ArticleInternational journal of molecular sciences2021

Prolonged Transcriptional Consequences in Survivors of Sepsis.

Krzysztof Laudanski, James Soh, Matthew DiMeglio, Kathleen E Sullivan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Animals : an open access journal from MDPI · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Krzysztof LaudanskiDepartment of Anesthesiology and Critical Care, The University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7373-0851
James SohDepartment of Neurology, The University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-3509-3027
Matthew DiMeglioSchool of Medicine, Jefferson University, Philadelphia, PA 19104, USA.ORCID 0000-0001-9105-5995
Kathleen E SullivanDivision of Allergy and Immunology, Children Hospital Philadelphia, Philadelphia, PA 19104, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Epigenetic mediated long-term aberrations in myeloid cells after critical illnessK23GM120630 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LAUDANSKI, KRZYSZTOF · 2017 to 2020
$783k
NIGMS NIH HHS 1K23GM120630-01A1
6 · The paper itself

Abstract

Survivors of sepsis often suffer from prolonged post-critical illness syndrome secondary to the immune system's reprogramming. It is unclear if this process is static and pervasive due to methodological difficulties studying long-term outcomes of sepsis. The purpose of this study is to evaluate transcriptional profiles longitudinally in

Indexed as

AnimalsCritical IllnessDrosophila melanogasterEscherichia coliGene Expression ProfilingLongevityMicroRNAsOxidative StressRNA-SeqSepsisSignal TransductionSurvivorsTranscription, GeneticTranscriptomeMicroRNAsbacteremiaDrosophila melanogastergenomic profilingglutathione pathwaygram-negativelong-termmetabolomicmiRNApost-septic syndromeRNA-seqsepsissurvival

Identifiers

PMID34063857
PMCPMC8196560
OpenAlexW3165812645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.