Evidence map›Paper›PMID 34063776›Full record

ArticleInternational journal of molecular sciences2021

An Integrated Transcriptomic Approach to Identify Molecular Markers of Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.

Erika T Rhone, Elissa Bardhi, Sai Vineela Bontha, Patrick D Walker, Jorge A Almenara, Catherine I Dumur, Helen Cathro, Daniel Maluf, Valeria Mas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Erika T RhoneDepartment of Pediatrics, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Elissa BardhiSurgical Sciences Division, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Sai Vineela BonthaCardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.
Patrick D WalkerArkana Laboratories, Little Rock, AR 72211, USA.
Jorge A AlmenaraAurora Diagnostics-Sonic Healthcare, Bernhardt Laboratories, Jacksonville, FL 32216, USA.
Catherine I DumurAurora Diagnostics-Sonic Healthcare, Bernhardt Laboratories, Jacksonville, FL 32216, USA.
Helen CathroDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
Daniel MalufDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Valeria MasSurgical Sciences Division, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USBernhardt LaboratoriesUniversity of Virginia · USArkana Laboratories · USEastern Virginia Medical School · US

Funding

Assessment of Donor Quality for Improving Kidney Transplant OutcomesR01DK109581 · NIDDK · UNIVERSITY OF VIRGINIA · PI Kellie J. Archer, Valeria Raquel Mas · 2017 to 2026
$4.0M
Dissecting the role of dynamic epigenome prompting pathways leading to kidney allograft fibrosisR01DK122682 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MAS, VALERIA RAQUEL · 2019 to 2023
$3.6M
Kidney Disease and InflammationT32DK072922 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2006 to 2020
$2.6M
Molecular pathways leading to chronic graft dysfunctionR01DK080074 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI MAS, VALERIA RAQUEL · 2008 to 2012
$1.8M
Molecular biomarkers associated with calcineurin inhibitor mediated kidney injuryR21DK100678 · NIDDK · UNIVERSITY OF VIRGINIA · PI MALUF, DANIEL GERMAN · 2014 to 2015
$435k
NIDDK NIH HHS R01 DK080074NIDDK NIH HHS R01 DK109581NIDDK NIH HHS R01DK109581NIDDK NIH HHS R01 DK122682NIDDK NIH HHS R01DK122682NIDDK NIH HHS R21DK100678NIDDK NIH HHS T32 DK072922NIDDK NIH HHS T32DK072922
6 · The paper itself

Abstract

Calcineurin inhibitors are highly efficacious immunosuppressive agents used in pediatric kidney transplantation. However, calcineurin inhibitor nephrotoxicity (CNIT) has been associated with the development of chronic renal allograft dysfunction and decreased graft survival. This study evaluated 37 formalin-fixed paraffin-embedded biopsies from pediatric kidney transplant recipients using gene expression profiling. Normal allograft samples (

Indexed as

BiomarkersBiopsyCalcineurin InhibitorsChildComputational BiologyGene Expression ProfilingGraft RejectionGraft SurvivalHumansImmunosuppressive AgentsKidneyKidney DiseasesKidney TransplantationMicroRNAsOxidative StressTranscriptomeBiomarkersCalcineurin InhibitorsImmunosuppressive AgentsMicroRNAscalcineurin inhibitor nephrotoxicitykidney transplantationpediatrics

Identifiers

PMID34063776
PMCPMC8196602
OpenAlexW3163262363

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.