Evidence map›Paper›PMID 34063751›Full record

ArticleInternational journal of molecular sciences2021

Omega-3 PUFAs Suppress IL-1β-Induced Hyperactivity of Immunoproteasomes in Astrocytes.

Emilia Zgorzynska, Barbara Dziedzic, Monika Markiewicz, Anna Walczewska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emilia ZgorzynskaDepartment of Cell-to-Cell Communication, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.ORCID 0000-0002-5411-3778
Barbara DziedzicDepartment of Cell-to-Cell Communication, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Monika MarkiewiczDepartment of Applied Biology, Research Institute of Horticulture, Konstytucji 3 Maja 1/3, 96-100 Skierniewice, Poland.ORCID 0000-0002-5900-5557
Anna WalczewskaDepartment of Cell-to-Cell Communication, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Medical University of Lodz · PLInstytut Ogrodnictwa – Państwowy Instytut Badawczy · PL

Funding

Uniwersytet Medyczny w Lodzi 502-03/0-079-04/502-04-035Uniwersytet Medyczny w Lodzi 503/0-079-04/503-01-001
6 · The paper itself

Abstract

The role of immunoproteasome (iP) in astroglia, the cellular component of innate immunity, has not been clarified. The results so far indicate that neuroinflammation, a prominent hallmark of Alzheimer's disease, strongly activates the iP subunits expression. Since omega-3 PUFAs possess anti-inflammatory and pro-resolving activity in the brain, we investigated the effect of DHA and EPA on the gene expression of constitutive (β1 and β5) and inducible (iβ1/LMP2 and iβ5/LMP7) proteasome subunits and proteasomal activity in IL-1β-stimulated astrocytes. We found that both PUFAs downregulated the expression of IL-1β-induced the iP subunits, but not the constitutive proteasome subunits. The chymotrypsin-like activity was inhibited in a dose-dependent manner by DHA, and much strongly in the lower concentration by EPA. Furthermore, we established that C/EBPα and C/EBPβ transcription factors, being the

Indexed as

AnimalsAnti-Inflammatory AgentsAstrocytesCCAAT-Enhancer-Binding Protein-alphaCCAAT-Enhancer-Binding Protein-betaConnexin 43Docosahexaenoic AcidsDown-RegulationEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedGap JunctionsGene ExpressionInflammationInterleukin-1betaProteasome Endopeptidase ComplexAnti-Inflammatory AgentsCCAAT-Enhancer-Binding Protein-alphaCCAAT-Enhancer-Binding Protein-betaConnexin 43Docosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedIL1B protein, ratInterleukin-1betaProteasome Endopeptidase ComplexastrocytesC/EBPsconnexin 43docosahexaenoic acideicosapentaenoic acidimmunoproteasome

Identifiers

PMID34063751
PMCPMC8196670
OpenAlexW3163986010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.