Evidence map›Paper›PMID 34063745›Full record

ArticleBiology2021

Altered Expression of Candidate Genes in Mayer-Rokitansky-Küster-Hauser Syndrome May Influence Vaginal Keratinocytes Biology: A Focus on Protein Kinase X.

Paola Pontecorvi, Francesca Megiorni, Simona Camero, Simona Ceccarelli, Laura Bernardini, Anna Capalbo, Eleni Anastasiadou, Giulia Gerini, Elena Messina, Giorgia Perniola and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Paola PontecorviDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-2392-3775
Francesca MegiorniDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-3705-3248
Simona CameroDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0001-8286-3640
Simona CeccarelliDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0001-8789-7719
Laura BernardiniDivision of Medical Genetics, IRCCS Casa Sollievo della Sofferenza Foundation-Viale Cappuccini, 1, 71013 San Giovanni Rotondo (FG), Italy.ORCID 0000-0002-3554-2817
Anna CapalboDivision of Medical Genetics, IRCCS Casa Sollievo della Sofferenza Foundation-Viale Cappuccini, 1, 71013 San Giovanni Rotondo (FG), Italy.
Eleni AnastasiadouDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-0212-6734
Giulia GeriniDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.
Elena MessinaDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0002-7182-2883
Giorgia PerniolaDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.
Pierluigi Benedetti PaniciDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.
Paola GrammaticoDivision of Medical Genetics, Department of Molecular Medicine, Sapienza University of Rome-San Camillo-Forlanini Hospital, Circonvallazione Gianicolense, 87, 00152 Rome, Italy.ORCID 0000-0002-6864-2574
Antonio PizzutiDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.
Cinzia MarcheseDepartment of Experimental Medicine, Sapienza University of Rome-Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0002-9280-8917
Sapienza University of Rome · ITCasa Sollievo della Sofferenza · ITCarlo Forlanini Hospital · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca F8ZB89Sapienza Università di Roma RM11916B7040B1F8Sapienza Università di Roma RM1201729DF399F4
6 · The paper itself

Abstract

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare and complex disease defined by congenital aplasia of the vagina and uterus in 46,XX women, often associated with kidney and urinary tract anomalies. The aetiopathogenesis of MRKH syndrome is still largely unknown. Herein, we investigated the role of selected candidate genes in the aetiopathogenesis of MRKH syndrome, with a focus on

Indexed as

cell migrationEMTgene expressiongenital tract developmentHOX genesMayer–Rokitansky–Küster–Hauser syndromePRKXtissue morphogenesisvaginal keratinocyte

Identifiers

PMID34063745
PMCPMC8223793
OpenAlexW3162041080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.