Evidence map›Paper›PMID 34063742›Full record

ArticleInternational journal of molecular sciences2021

Osteogenesis of 3D-Printed PCL/TCP/bdECM Scaffold Using Adipose-Derived Stem Cells Aggregates; An Experimental Study in the Canine Mandible.

Joon Seok Lee, Tae Hyun Park, Jeong Yeop Ryu, Dong Kyu Kim, Eun Jung Oh, Hyun Mi Kim, Jin-Hyung Shim, Won-Soo Yun, Jung Bo Huh, Sung Hwan Moon and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  9. The Application of 3D Anatomy for Teaching Veterinary Clinical Neurology.Animals : an open access journal from MDPI · 2023
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  14. Osteoclastogenesis and Osteogenesis.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Joon Seok LeeDepartment of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Tae Hyun ParkDepartment of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0002-0373-9156
Jeong Yeop RyuDepartment of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0003-2812-5051
Dong Kyu KimTINA Aesthetic Surgical Clinic, Daegu 41938, Korea.
Eun Jung OhDepartment of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0002-5139-9870
Hyun Mi KimDepartment of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Jin-Hyung ShimDepartment of Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-si 15073, Gyeonggi-do, Korea.
Won-Soo YunDepartment of Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-si 15073, Gyeonggi-do, Korea.
Jung Bo HuhDepartment of Prosthodontics, Dental Research Institute, Institute of Translational Dental Science, School of Dentistry, Pusan National University, Yangsan-si 50612, Korea.
Sung Hwan MoonResearch Institute, T&R Biofab Co., Ltd. 242 Pangyo-ro, Seongnam-si 13487, Gyeonggi-do, Korea.
Seong Soo KangCollege of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea.
Ho Yun ChungDepartment of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0001-7359-3044
Kyungpook National University · KRTech University of Korea · KRChonnam National University · KRPusan National University Dental Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional (3D) printing is perceived as an innovative tool for change in tissue engineering and regenerative medicine based on research outcomes on the development of artificial organs and tissues. With advances in such technology, research is underway into 3D-printed artificial scaffolds for tissue recovery and regeneration. In this study, we fabricated artificial scaffolds by coating bone demineralized and decellularized extracellular matrix (bdECM) onto existing 3D-printed polycaprolactone/tricalcium phosphate (PCL/TCP) to enhance osteoconductivity and osteoinductivity. After injecting adipose-derived stem cells (ADSCs) in an aggregate form found to be effective in previous studies, we examined the effects of the scaffold on ossification during mandibular reconstruction in beagle dogs. Ten beagles were divided into two groups: group A (PCL/TCP/bdECM + ADSC injection;

Indexed as

AdipocytesAdipose TissueAnimalsBone RegenerationCalcium PhosphatesDogsExtracellular MatrixMandibleOsteoblastsOsteogenesisPolyestersPrinting, Three-DimensionalStem CellsTissue EngineeringTissue ScaffoldsCalcium PhosphatespolycaprolactonePolyesterstricalcium phosphate3D-printed PCL/TCP/bdECM scaffoldadipose-derived stem cellsaggregateosteogenesis

Identifiers

PMID34063742
PMCPMC8196585
OpenAlexW3160118388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.