Evidence map›Paper›PMID 34063734›Full record

ArticleInternational journal of molecular sciences2021

Caffeine Inhibits Direct and Indirect Angiogenesis in Zebrafish Embryos.

Ram Manohar Basnet, Daniela Zizioli, Alessia Muscò, Dario Finazzi, Sandra Sigala, Elisa Rossini, Chiara Tobia, Jessica Guerra, Marco Presta, Maurizio Memo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pro-Angiogenetic Effects of Purified Extracts fromCurrent issues in molecular biology · 2022
    Article
  10. Zebrafish-An Optimal Model in Experimental Oncology.Molecules (Basel, Switzerland) · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ram Manohar BasnetUnit of Pharmacology, DMMT, University of Brescia, 25123 Brescia, Italy.
Daniela ZizioliUnit of Biotechnology, DMMT, University of Brescia, 25123 Brescia, Italy.
Alessia MuscòUnit of Pharmacology, DMMT, University of Brescia, 25123 Brescia, Italy.
Dario FinazziUnit of Biotechnology, DMMT, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-5176-2839
Sandra SigalaUnit of Pharmacology, DMMT, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-3294-4121
Elisa RossiniUnit of Pharmacology, DMMT, University of Brescia, 25123 Brescia, Italy.
Chiara TobiaUnit of Experimental Oncology and Immunology, DMMT, University of Brescia, 25123 Brescia, Italy.
Jessica GuerraUnit of Experimental Oncology and Immunology, DMMT, University of Brescia, 25123 Brescia, Italy.
Marco PrestaUnit of Experimental Oncology and Immunology, DMMT, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-4398-8376
Maurizio MemoUnit of Pharmacology, DMMT, University of Brescia, 25123 Brescia, Italy.
University of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we report the effects of caffeine on angiogenesis in zebrafish embryos both during normal development and after exposure to Fibroblast Growth Factor 2 (FGF2). As markers of angiogenesis, we measured the length and width of intersegmental vessels (ISVs), performed whole-mount in situ hybridization with

Indexed as

AnimalsCaffeineCell Line, TumorEmbryonic DevelopmentEmbryo, NonmammalianFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalHeterograftsHumansIn Situ HybridizationNeovascularization, PathologicNeovascularization, PhysiologicZebrafishCaffeineFibroblast Growth Factor 2angiogenesiscaffeineembryonic vascular developmentFGF2methylxanthineszebrafish

Identifiers

PMID34063734
PMCPMC8124397
OpenAlexW3157199815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.