Evidence map›Paper›PMID 34063730›Full record

ArticleInternational journal of molecular sciences2021

Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice.

Christian Stetter, Simon Lopez-Caperuchipi, Sarah Hopp-Krämer, Michael Bieber, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weißenberger

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christian StetterDepartment of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
Simon Lopez-CaperuchipiDepartment of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.ORCID 0000-0002-1057-3086
Sarah Hopp-KrämerDepartment of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
Michael BieberDepartment of Neurology, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.ORCID 0000-0002-5535-6480
Christoph KleinschnitzDepartment of Neurology, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
Anna-Leena SirénDepartment of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.ORCID 0000-0002-2217-0081
Christiane Albert-WeißenbergerDepartment of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DE

Funding

Bundesministerium für Bildung und Forschung EU-ERA-NET NEURON CnsAFlame (BMBF 01EW1502B)Deutsche Forschungsgemeinschaft Collaborative Research Center TR240 (project B04)Deutsche Forschungsgemeinschaft Research Unit FOR2879Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg E-313
6 · The paper itself

Abstract

Based on recent findings that show that depletion of factor XII (FXII) leads to better posttraumatic neurological recovery, we studied the effect of FXII-deficiency on post-traumatic cognitive and behavioral outcomes in female and male mice. In agreement with our previous findings, neurological deficits on day 7 after weight-drop traumatic brain injury (TBI) were significantly reduced in FXII

Indexed as

AnimalsBrainBrain Injuries, TraumaticCognitive DysfunctionCorticosteroneDisease Models, AnimalFactor XIIFactor XII DeficiencyHumansMemoryMiceMice, KnockoutPlatelet AggregationPlatelet Glycoprotein GPIb-IX ComplexCorticosteroneFactor XIIPlatelet Glycoprotein GPIb-IX Complexclosed head injurycontact-kinin systemCrespi effectIntelliCageobject recognition memorystress

Identifiers

PMID34063730
PMCPMC8124758
OpenAlexW3159111348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.