Evidence map›Paper›PMID 34063662›Full record

ArticleDentistry journal2021

Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque.

Sakari Nikinmaa, Niina Moilanen, Timo Sorsa, Juha Rantala, Heikki Alapulli, Anja Kotiranta, Petri Auvinen, Esko Kankuri, Jukka H Meurman, Tommi Pätilä

11 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Dentistry journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 11 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05698823 nacompletednot on this mapstarted 2023, after this paper: background citation

Regular Home-use of Dual-light Photodynamic Therapy in the Management of Chronic Stage III-IV Periodontitis

TypeinterventionalSponsorKoite Health OyRan2023 to 2026Enrolled56ConditionsPeriodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized SevereArmsLumoral Treatment
NCT05720104 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

Effect of Regular Antibacterial Photodynamic Therapy on Oral Hygiene in the Elderly 24-hour Care Residents

TypeinterventionalSponsorKoite Health OyRan2023 to 2026Enrolled0ConditionsInflamed Gums, Dryness Oral, PlaqueArmsLumoral Treatment, Standard oral hygiene instructions
NCT05825742 nacompletednot on this mapstarted 2023, after this paper: background citation

Efficacy of Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment - Randomized, Controlled Clinical Study

TypeinterventionalSponsorKoite Health OyRan2023 to 2025Enrolled40ConditionsOrthodontic Appliance Complication, Plaque, Dental, Gingival InflammationArmsLumoral Treatment, Standard oral health instructions
NCT05853679 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Regular Antibacterial Photodynamic Therapy on Oral Hygiene in Elderly Residents of a 24-hour Care Facility

TypeinterventionalSponsorKoite Health OyRan2022 to 2023Enrolled31ConditionsDental Plaque, Pus Collection, Oral Disease, Dryness OralArmsLumoral Treatment, Standard oral hygiene instructions according to the Finnish Dental Association
NCT06017817 narecruitingnot on this mapstarted 2024, after this paper: background citation

Regular Home-use of Antibacterial Photodynamic Therapy in the Management of Peri-implantitis

TypeinterventionalSponsorKoite Health OyRan2024 to 2026Enrolled80ConditionsPeri-Implantitis, Plaque, DentalArmsLumoral Treatment, Standard oral hygiene instructions, Scaling and root planing (SRP, surgical anti-infective peri-implantitis treatment
NCT06041828 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Impact of Regular Home-use Dual Light Photodynamic Therapy in the Prevention of Osteolysis After Dental Implant Surgery

TypeinterventionalSponsorKoite Health OyRan2025 to 2025Enrolled0ConditionsOsteolysis, Dental ImplantsArmsLumoral Treatment, Standard oral hygiene
NCT06286501 narecruitingnot on this mapstarted 2024, after this paper: background citation

Identification of Adolescent Patients at Risk of Oral Diseases and Targeting of Preventive Treatment, and the Use of Antibacterial Photodynamic Therapy as an Adjunctive Treatment Method

TypeinterventionalSponsorWellbeing Services County of PirkanmaaRan2024 to 2025Enrolled120ConditionsDental Caries in Children, Dental Plaque, Tooth Decay, PeriodontitisArmsLumoral Treatment, Standard, personalized oral health care
NCT06576063 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of the Regular Use of Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons Living at Home or at Care Homes

TypeinterventionalSponsorKoite Health OyRan2025 to 2027Enrolled100ConditionsDental Plaque, Bleeding of Subgingival Space, Oral ComplicationArmsLumoral Treatment, Standard oral hygiene methods
NCT06859866 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis: A Post-Marketing Interventional Pilot Study With a Medical Device

TypeinterventionalSponsorKoite Health OyRan2025 to 2027Enrolled30ConditionsPeri-implant MucositisArmsStandard oral hygiene, The addition of home-based dual-light photodynamic therapy (Lumorinse® + Lumoral®)
NCT06860321 nacompletednot on this mapstarted 2025, after this paper: background citation

Photodynamic Treatment in the Management of Residual Biofilm - a Crossover Study

TypeinterventionalSponsorKoite Health OyRan2025 to 2025Enrolled20ConditionsHealthy Adults, Plaque, DentalArmsAdjunct antibacterial home-use dual-light medical device, Regular oral self care
NCT06877546 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Photodynamic Treatment as Part of Oral Healthcare on Persons With Sjögren's Syndrome

TypeinterventionalSponsorKoite Health OyRan2025 to 2025Enrolled16ConditionsSjogren Syndrome, XerostomiaArmsLumoral treatment
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Peri-Implant Diseases: Enhanced Antibacterial Photodynamic Therapy.Clinical and experimental dental research · 2025
    Trial
  4. Article
  5. Article
  6. Article
  7. Antibacterial Efficacy of Dual-dye and Dual Laser Photodynamic Therapy on Oral Biofilms ofInternational journal of clinical pediatric dentistry · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Periodontal Disease - A Late Complication of Head and Neck Cancer Radiotherapy.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Sakari NikinmaaDepartment of Neuroscience and Biomedical Engineering, Aalto University, 12200 Espoo, Finland.
Niina MoilanenDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Timo SorsaDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Juha RantalaDepartment of Neuroscience and Biomedical Engineering, Aalto University, 12200 Espoo, Finland.
Heikki AlapulliDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Anja KotirantaDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Petri AuvinenInstitute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland.ORCID 0000-0002-3947-4778
Esko KankuriFaculty of Medicine, Department of Pharmacology, University of Helsinki, 00290 Helsinki, Finland.ORCID 0000-0002-2193-8773
Jukka H MeurmanDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.ORCID 0000-0001-6702-6836
Tommi PätiläDepartment of Congenital Heart Surgery and Organ Transplantation, New Children's Hospital, University of Helsinki, 00290 Helsinki, Finland.
University of Helsinki · FIAalto University · FI

Funding

Business Finland 4364/31/2016
6 · The paper itself

Abstract

aimThis study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque.

methodsFifteen healthy adults were assigned to this four-day randomized study. After rinsing with ICG, 100 J/cm

resultsaPDT administration was preformed successfully and plaque-specifically with the combination of ICG and the applicator. Total plaque area and endpoint MMP-8 levels were reduced on the aPDT-treatment side. aPDT reduced

conclusionICG-assisted aPDT reduces plaque forming bacteria and exerts anti-inflammatory and anti-proteolytic effects.

Indexed as

antibacterial photodynamic therapydental plaquegingivitis

Identifiers

PMID34063662
PMCPMC8147628
OpenAlexW3157092943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 5 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.