Evidence map›Paper›PMID 34063650›Full record

ArticleMolecules (Basel, Switzerland)2021

Identification of Molecules from Coffee Silverskin That Suppresses Myostatin Activity and Improves Muscle Mass and Strength in Mice.

Jeong Han Kim, Jae Hong Kim, Jun-Pil Jang, Jae-Hyuk Jang, Deuk-Hee Jin, Yong Soo Kim, Hyung-Joo Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jeong Han KimDepartment of Marine Molecular Bioscience, Gangneung-Wonju National University, Gangneung-si 25457, Korea.
Jae Hong KimDepartment of Marine Molecular Bioscience, Gangneung-Wonju National University, Gangneung-si 25457, Korea.
Jun-Pil JangAnticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea.
Jae-Hyuk JangNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea.ORCID 0000-0002-4363-4252
Deuk-Hee JinDepartment of Marine Molecular Bioscience, Gangneung-Wonju National University, Gangneung-si 25457, Korea.
Yong Soo KimDepartment of Human Nutrition, Food and Animal Sciences, University of Hawaii, 1955 East-West Rd., Honolulu, HI 96822, USA.
Hyung-Joo JinDepartment of Human Nutrition, Food and Animal Sciences, University of Hawaii, 1955 East-West Rd., Honolulu, HI 96822, USA.ORCID 0000-0001-6570-359X
Gangneung–Wonju National University · KRKorea Research Institute of Bioscience and Biotechnology · KRUniversity of Hawaii System · US

Funding

National Research Foundation of Korea 2017R1A2B4004152
6 · The paper itself

Abstract

Coffee has been shown to attenuate sarcopenia, the age-associated muscle atrophy. Myostatin (MSTN), a member of the TGF-β growth/differentiation factor superfamily, is a potent negative regulator of skeletal muscle mass, and MSTN-inhibition increases muscle mass or prevents muscle atrophy. This study, thus, investigated the presence of MSTN-inhibitory capacity in coffee extracts. The ethanol-extract of coffee silverskin (CSE) but not other extracts demonstrated anti-MSTN activity in a pGL3-(CAGA)

Indexed as

Administration, OralAnimalsBlood GlucoseBody WeightBone and BonesCoffeeEthanolFatty Acids, NonesterifiedInhibitory Concentration 50MaleMetabolic SyndromeMiceMice, Inbred ICRMusclesMuscle, SkeletalMyostatinBlood GlucoseCoffeeEthanolFatty Acids, NonesterifiedMyostatinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseRNA, MessengerSolventsTransforming Growth Factor betaUcp1 protein, mouseUncoupling Protein 1coffee silverskinmuscle atrophymyostatin inhibitionβN-arachinoyl−5-hydroxytryptamideβN-behenoyl−5-hydroxytryptamid

Identifiers

PMID34063650
PMCPMC8124993
OpenAlexW3158810354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.