Evidence map›Paper›PMID 34063647›Full record

ArticleCells2021

ARC

Juliana Bezerra Medeiros de Lima, Lucas Kniess Debarba, Alan C Rupp, Nathan Qi, Chidera Ubah, Manal Khan, Olesya Didyuk, Iven Ayyar, Madelynn Koch, Darleen A Sandoval and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Growth Hormone, Hypothalamic Inflammation, and Aging.Journal of obesity & metabolic syndrome · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Growth Hormone and Insulin-Like Growth Factor 1 Regulation of Nonalcoholic Fatty Liver Disease.The Journal of clinical endocrinology and metabolism · 2022 · on this map
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Juliana Bezerra Medeiros de LimaDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.ORCID 0000-0003-1372-5177
Lucas Kniess DebarbaDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.
Alan C RuppDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nathan QiDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1919-9171
Chidera UbahDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.
Manal KhanDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.
Olesya DidyukDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.
Iven AyyarDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.ORCID 0000-0002-2257-0763
Madelynn KochDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.
Darleen A SandovalDepartment of Pediatrics, Anschutz Medical Campus, University of Colorado, Denver, CO 80217, USA.ORCID 0000-0003-3669-3278
Marianna SadagurskiDepartment of Biological Sciences, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA.ORCID 0000-0002-8203-4612
Wayne State University · USUniversity of Michigan · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
American Diabetes Association Research Foundation 1-lB-IDF-063NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS U2C DK110768
6 · The paper itself

Abstract

The growth hormone receptor (GHR) is expressed in brain regions that are known to participate in the regulation of energy homeostasis and glucose metabolism. We generated a novel transgenic mouse line (GHR

Indexed as

AnimalsArcuate Nucleus of HypothalamusEnergy MetabolismFastingGlucoseGlycolysisMiceMuscle, SkeletalNeuronsPostprandial PeriodReceptors, SomatotropinGlucoseReceptors, Somatotropinarcuate nucleus of the hypothalamusenergy homeostasisglucose metabolismgrowth hormone receptor

Identifiers

PMID34063647
PMCPMC8147615
OpenAlexW3157684336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.