Evidence map›Paper›PMID 34063635›Full record

ReviewMolecules (Basel, Switzerland)2021

Beneficial Effects of Green Tea Catechins on Female Reproductive Disorders: A Review.

Datu Agasi Mohd Kamal, Norizam Salamt, Siti Sarah Mohamad Zaid, Mohd Helmy Mokhtar

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06768086 (3 Months Preoperative Administration of Eutris Plus Prior Hysteroscopic Myomectomy), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06768086 completednot on this mapstarted 2025, after this paper: background citation

3 Months Preoperative Administration of Eutris Plus Prior Hysteroscopic Myomectomy: a Pilot Study

Typeobservational_patient_registrySponsorCentro di Ricerca Clinica SalentinoRan2025 to 2025Enrolled90ConditionsUterine Fibroids, Hysteroscopic Myomectomy, Treatment Compliance, Patient ComplianceArmsHysteroscopic myomectomy
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Natural Products Targeting Oxidative Stress-Inflammation Crosstalk in Endometriosis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Datu Agasi Mohd KamalDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0003-0836-9702
Norizam SalamtDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Siti Sarah Mohamad ZaidDepartment of Environment, Faculty of Forestry and Environment, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Mohd Helmy MokhtarDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-7801-6358
National University of Malaysia · MYUniversiti of Malaysia Sabah · MYUniversiti Putra Malaysia · MY

Funding

Universiti Kebangsaan Malaysia GUP-2018-146
6 · The paper itself

Abstract

Tea is one of the most widely consumed beverages worldwide after water, and green tea accounts for 20% of the total tea consumption. The health benefits of green tea are attributed to its natural antioxidants, namely, catechins, which are phenolic compounds with diverse beneficial effects on human health. The beneficial effects of green tea and its major bioactive component, (-)-epigallocatechin-3-gallate (EGCG), on health include high antioxidative, osteoprotective, neuroprotective, anti-cancer, anti-hyperlipidemia and anti-diabetic effects. However, the review of green tea's benefits on female reproductive disorders, including polycystic ovary syndrome (PCOS), endometriosis and dysmenorrhea, remains scarce. Thus, this review summarises current knowledge on the beneficial effects of green tea catechins on selected female reproductive disorders. Green tea or its derivative, EGCG, improves endometriosis mainly through anti-angiogenic, anti-fibrotic, anti-proliferative and proapoptotic mechanisms. Moreover, green tea enhances ovulation and reduces cyst formation in PCOS while improving generalised hyperalgesia, and reduces plasma corticosterone levels and uterine contractility in dysmenorrhea. However, information on clinical trials is inadequate for translating excellent findings on green tea benefits in animal endometriosis models. Thus, future clinical intervention studies are needed to provide clear evidence of the green tea benefits with regard to these diseases.

Indexed as

Angiogenesis InhibitorsAnimalsAntioxidantsApoptosisCamellia sinensisCatechinCell ProliferationCorticosteroneCross-Sectional StudiesDisease Models, AnimalDysmenorrheaEndometriosisFemaleHumansMicePlant ExtractsAngiogenesis InhibitorsAntioxidantsCatechinCorticosteroneepigallocatechin gallatePlant ExtractsTeacatechindysmenorrheaendometriosisepigallocatechin-3-gallatepolycystic ovary syndrome

Identifiers

PMID34063635
PMCPMC8124874
OpenAlexW3158200651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.