Evidence map›Paper›PMID 34063608›Full record

ArticleInternational journal of molecular sciences2021

p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries.

Gagandeep Kaur, Isaac K Sundar, Irfan Rahman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gagandeep KaurDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Isaac K SundarDepartment of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0001-6742-3460
Irfan RahmanDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0003-2274-2454
University of Rochester Medical Center · USUniversity of Kansas Medical Center · US

Funding

TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
Molecular clock dysfunction in lung cellular senescence by environmental tobacco smokeR01ES029177 · NIEHS · UNIVERSITY OF ROCHESTER · PI RAHMAN, IRFAN · 2019 to 2023
$1.7M
NIA NIH HHS U54 AG075931NIEHS NIH HHS R01 ES029177NIH HHS 1R01HL135613, R01 ES029177, HL137738 and R01 HL133404
6 · The paper itself

Abstract

Cellular senescence and lung aging are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). COPD progresses with aging, and chronic smoking is the key susceptibility factor in lung pathological changes concurrent with mitochondrial dysfunction and biological aging. However, these processes involving cigarette smoke (CS)-mediated lung cellular senescence are difficult to distinguish. One of the impediments to studying cellular senescence in relation to age-related lung pathologies is the lack of a suitable in vivo model. In view of this, we provide evidence that supports the suitability of p16-3MR mice to studying cellular senescence in CS-mediated and age-related lung pathologies. p16-3MR mice have a trimodal reporter fused to the promoter of the p16

Indexed as

AgingAnimalsCellular SenescenceCigarette SmokingCyclin-Dependent Kinase Inhibitor p16Disease Models, AnimalEpithelial CellsFibronectinsGene Expression RegulationHumansLung InjuryMatrix Metalloproteinase 12Matrix Metalloproteinase 9Pulmonary Disease, Chronic ObstructivePulmonary EmphysemaSerpin E2Cyclin-Dependent Kinase Inhibitor p16Fibronectinsmatrix metallopeptidase 12, mouseMatrix Metalloproteinase 12Matrix Metalloproteinase 9Mmp9 protein, mouseSerpin E2Serpine2 protein, mousecellular senescencecigarette smokeCOPDmitochondrial dysfunctionp16SASP

Identifiers

PMID34063608
PMCPMC8125702
OpenAlexW3157981755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.