Evidence map›Paper›PMID 34063607›Full record

ArticleInternational journal of molecular sciences2021

Interaction between the Renin-Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis.

Mariana Ferreira-Duarte, Tiago Rodrigues-Pinto, Teresa Sousa, Miguel A Faria, Maria Sofia Rocha, Daniela Menezes-Pinto, Marisa Esteves-Monteiro, Fernando Magro, Patrícia Dias-Pereira, Margarida Duarte-Araújo and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. The Angiotensin ATPharmacological reviews · 2022
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mariana Ferreira-DuarteLaboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Tiago Rodrigues-PintoLaboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Teresa SousaUnit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Miguel A FariaLAQV-REQUIMTE, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Maria Sofia RochaLaboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Daniela Menezes-PintoLaboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Marisa Esteves-MonteiroLaboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Fernando MagroUnit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.ORCID 0000-0003-2634-9668
Patrícia Dias-PereiraDepartment of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), 4050-313 Porto, Portugal.
Margarida Duarte-AraújoLAQV-REQUIMTE, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.ORCID 0000-0003-4727-727X
Manuela MoratoLaboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.ORCID 0000-0002-9509-0613
Universidade do Porto · PT

Funding

Fundação para a Ciência e Tecnologia (FCT) UIDB 50006/2020GEDII - Grupo de Estudos da Doença Inflamatória Intestinal
6 · The paper itself

Abstract

Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT

Indexed as

Angiotensin IIAngiotensin Receptor AntagonistsAnimalsColitisColonEnteric Nervous SystemHumansInflammatory Bowel DiseasesInterstitial Cells of CajalMaleMuscle ContractionMuscle, Smooth, VascularNeurogliaNitric OxideRatsReceptor, Angiotensin, Type 1Angiotensin IIAngiotensin Receptor AntagonistsNitric OxideReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2angiotensin IIAT1 and AT2 receptorscolonic dysmotilityEGCenteric glial cellsIBDICCinflammatory bowel diseaseinterstitial cells of Cajalnitric oxideTNBS-induced colitis

Identifiers

PMID34063607
PMCPMC8125095
OpenAlexW3157258766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.