Evidence map›Paper›PMID 34063571›Full record

ArticleCells2021

Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.

Yuria Hori, Reiho Tsutsumi, Kento Nasu, Alex Boateng, Yasuhiko Ashikari, Masaharu Sugiura, Makoto Nakajima, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Turmeric (Pharmaceutical biology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Pharmacological Activities of Turmerones.Current medicinal chemistry · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yuria HoriDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Reiho TsutsumiDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Kento NasuDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Alex BoatengGraduate School of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.ORCID 0000-0002-8739-6452
Yasuhiko AshikariDepartment of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Masaharu SugiuraGraduate School of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Makoto NakajimaDepartment of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Yuki KurauchiDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Akinori HisatsuneDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Hiroshi KatsukiDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.ORCID 0000-0001-7595-3154
Takahiro SekiDepartment of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Kumamoto University · JPSojo University · JP

Funding

Japan Society for the Promotion of Science 16K08276Japan Society for the Promotion of Science 19K07123The Joint Research Program of the Biosignal Research Center, Kobe University 191005The Joint Research Program of the Biosignal Research Center, Kobe University 281007
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. The inflammatory activation of microglia participates in dopaminergic neurodegeneration in PD. Therefore, chemicals that inhibit microglial activation are considered to have therapeutic potential for PD. Aromatic (ar)-turmerone is a main component of turmeric oil extracted from

Indexed as

AnimalsCell LineCells, CulturedDopaminergic NeuronsKetonesMesencephalonMiceMicrogliaNeuroprotective AgentsRatsRats, WistarSesquiterpenesar-turmeroneKetonesNeuroprotective AgentsSesquiterpenesaromatic-turmeronedopaminergic neuronsmicrogliaNrf2

Identifiers

PMID34063571
PMCPMC8147616
OpenAlexW3159223343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.