ArticleJournal of clinical medicine2021
Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associated with Progression and Development of Vision-Threatening Complications: A 5-Year Longitudinal Study.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Automated Volumetric Segmentation of Microaneurysms on OCT Using Artificial Intelligence.ArXiv · 2026Article
- Content-based retrieval of fundus images and diabetic retinopathy detection using variants of local texture features.Radiological physics and technology · 2026Article
- BigEye: a clinically interpretable deep learning framework for diabetic retinopathy detection and stage prediction.Scientific reports · 2026Article
- Diabetic retinal disease.Nature reviews. Disease primers · 2025Review
- Microaneurysm Counting as a Biomarker for the Hyperperfusion Stage of Nonproliferative Diabetic Retinopathy.Ophthalmology and therapy · 2025Article
- Use of artificial intelligence with retinal imaging in screening for diabetes-associated complications: systematic review.EClinicalMedicine · 2025Review
- Characteristics of Microaneurysm Size in Residual Edema After Intravitreal Injection of Faricimab for Diabetic Macular Edema.Journal of clinical medicine · 2024Article
- Correlation between Topographic Vessel Density and Retinal Thickness Changes in Patients with Diabetic Macular Edema Treated with Anti-VEGF Therapy: Is It a Suitable OCTA Biomarker?Journal of personalized medicine · 2023Article
- The relationship of diabetic retinopathy severity scales with frequency and surface area of diabetic retinopathy lesions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Quantification of Microvascular Lesions in the Central Retinal Field: Could It Predict the Severity of Diabetic Retinopathy?Journal of clinical medicine · 2023Article
- Artificial Intelligence for Diabetic Retinopathy Screening Using Color Retinal Photographs: From Development to Deployment.Ophthalmology and therapy · 2023Review
- Role of Microaneurysms in the Pathogenesis and Therapy of Diabetic Macular Edema: A Descriptive Review.Medicina (Kaunas, Lithuania) · 2023Review
- Predictive factors for microvascular recovery after treatments for diabetic retinopathy.BMC ophthalmology · 2023Article
- Current and Future Treatments for Diabetic Retinopathy.Pharmaceutics · 2022Article
- Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy.Ophthalmology and therapy · 2022Article
- Characterization of Risk Profiles for Diabetic Retinopathy Progression.Journal of personalized medicine · 2021Article
- Retinal Neurodegeneration in Different Risk Phenotypes of Diabetic Retinal Disease.Frontiers in neuroscience · 2021Article
- Progression of Capillary Hypoperfusion in Advanced Stages of Nonproliferative Diabetic Retinopathy: 6-month Analysis of RICHARD Study.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAnalysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications.
methods212 individuals with type 2 diabetes (T2D; ETDRS grades 20 and 35) were evaluated annually in a 5-year prospective, longitudinal study, by color fundus photography and optical coherence tomography. Endpoints were diabetic macular edema (DME) or proliferative retinopathy (PDR). MAT analysis included determination of MA formation and disappearance rates, automatically assessed using the RetMarkerDR
resultsOf the 212 individuals, 172 completed the 5-year follow-up study or developed an endpoint (n = 27). MAT calculated at 1 year showed a significant difference between groups of endpoint developments (
conclusionsMAT is an indicator of the development of DME and/or PDR as well as of DR severity progression in T2D individuals with mild retinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.