Evidence map›Paper›PMID 34063468›Full record

ArticleSensors (Basel, Switzerland)2021

Ability of a Set of Trunk Inertial Indexes of Gait to Identify Gait Instability and Recurrent Fallers in Parkinson's Disease.

Stefano Filippo Castiglia, Antonella Tatarelli, Dante Trabassi, Roberto De Icco, Valentina Grillo, Alberto Ranavolo, Tiwana Varrecchia, Fabrizio Magnifica, Davide Di Lenola, Gianluca Coppola and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05887739 (Harmonic Ratio in Patients With GLUT1 Deficiency Syndrome), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05887739 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Harmonic Ratio in Patients With GLUT1 Deficiency Syndrome

TypeobservationalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2023 to 2026Enrolled32ConditionsGLUT1DS1, Dystonia, Gait Disorders, Neurologic, Gait AtaxiaArmsInertial gait analysis
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Observational
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  15. Neurophysiology of cerebellar ataxias and gait disorders.Clinical neurophysiology practice · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stefano Filippo CastigliaDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, 04100 Latina, Italy.ORCID 0000-0001-5329-5197
Antonella TatarelliDepartment of Human Neurosciences, University of Rome Sapienza, 00185 Rome, Italy.ORCID 0000-0002-1315-1743
Dante TrabassiDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, 04100 Latina, Italy.ORCID 0000-0002-4739-3441
Roberto De IccoMovement Analysis Research Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0001-9415-4948
Valentina GrilloMovement Analysis Research Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Alberto RanavoloDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL, Monte Porzio Catone, 00078 Rome, Italy.ORCID 0000-0002-0197-6166
Tiwana VarrecchiaDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL, Monte Porzio Catone, 00078 Rome, Italy.
Fabrizio MagnificaDepartment of Human Neurosciences, University of Rome Sapienza, 00185 Rome, Italy.ORCID 0000-0002-8802-5477
Davide Di LenolaDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, 04100 Latina, Italy.
Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, 04100 Latina, Italy.ORCID 0000-0002-8510-6925
Donatella FerrariU.O. Riabilitazione Neurologica, Istituto Chirurgico Ortopedico Traumatologico, Latina 04100, Italy.
Alessandro DenaroU.O. Riabilitazione Neurologica, Istituto Chirurgico Ortopedico Traumatologico, Latina 04100, Italy.
Cristina TassorelliMovement Analysis Research Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0003-1513-2113
Mariano SerraoDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, 04100 Latina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aims of this study were to assess the ability of 16 gait indices to identify gait instability and recurrent fallers in persons with Parkinson's disease (pwPD), regardless of age and gait speed, and to investigate their correlation with clinical and kinematic variables. The trunk acceleration patterns were acquired during the gait of 55 pwPD and 55 age-and-speed matched healthy subjects using an inertial measurement unit. We calculated the harmonic ratios (HR), percent recurrence, and percent determinism (RQAdet), coefficient of variation, normalized jerk score, and the largest Lyapunov exponent for each participant. A value of ≤1.50 for the HR in the antero-posterior direction discriminated between pwPD at Hoehn and Yahr (HY) stage 3 and healthy subjects with a 67% probability, between pwPD at HY 3 and pwPD at lower HY stages with a 73% probability, and it characterized recurrent fallers with a 77% probability. Additionally, HR in the antero-posterior direction was correlated with pelvic obliquity and rotation. RQAdet in the antero-posterior direction discriminated between pwPD and healthy subjects with 67% probability, regardless of the HY stage, and was correlated with stride duration and cadence. Therefore, HR and RQA

Indexed as

Gait Disorders, NeurologicParkinson DiseaseAccidental FallsGaitHumansPostural Balanceaccelerometryfallsgait disordersharmonic rationeurologicParkinson’s diseasepostural balancerecurrence quantification analysis

Identifiers

PMID34063468
PMCPMC8156709

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.