Evidence map›Paper›PMID 34063393›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Development and Validation of an RP-HPLC-PDA Method for Determination of Paracetamol, Caffeine and Tramadol Hydrochloride in Pharmaceutical Formulations.

Fernando J Pereira, Aida Rodríguez-Cordero, Roberto López, Luis C Robles, A Javier Aller

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Interpol Review of Drug Analysis 2019-2022.Forensic science international. Synergy · 2023
    Review
  9. Article
  10. Advanced Functionalized CeONanomaterials (Basel, Switzerland) · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernando J PereiraDepartment of Applied Chemistry and Physics, Area of Analytical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León, Spain.ORCID 0000-0003-3610-9182
Aida Rodríguez-CorderoDepartment of Applied Chemistry and Physics, Area of Analytical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León, Spain.
Roberto LópezDepartment of Applied Chemistry and Physics, Area of Physical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León, Spain.ORCID 0000-0001-5649-5370
Luis C RoblesDepartment of Applied Chemistry and Physics, Area of Analytical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León, Spain.
A Javier AllerDepartment of Applied Chemistry and Physics, Area of Analytical Chemistry, Faculty of Biological and Environmental Sciences, Campus de Vegazana, s/n, University of León, E-24071 León, Spain.ORCID 0000-0002-6454-7828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paracetamol (acetaminophen) (PAR), caffeine (CAF) and tramadol hydrochloride (TRA) are important drugs widely used for many clinical purposes. Determination of their contents is of the paramount interest. In this respect, a quick, simple and sensitive isocratic RP-HPLC method with photodiode array detection was developed for the determination of paracetamol, caffeine and tramadol in pharmaceutical formulations. An improved sensitive procedure was also evolved for tramadol using a fluorescence detector system. A C

Indexed as

caffeineHPLCparacetamolphotodiode-arraytramadol

Identifiers

PMID34063393
PMCPMC8156741

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.