ReviewInternational journal of molecular sciences2021
Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Comparison of Compound Lidocaine Cream and Lidocaine-Prilocaine Cream for Pain Management in Facial Rejuvenation: A Randomized Controlled Trial.Journal of cosmetic dermatology · 2026Trial
- Isolation of plant-derived exosome-like nanovesicles (PDENs) fromFuture science OA · 2026Article
- An Assessment of In Vitro Permeation Testing Finite Dose Methodology.AAPS PharmSciTech · 2026Article
- Beyond antifungals: vaginal ceramides as a barrier-restorative strategy for recurrent vulvovaginal candidiasis in Ehlers-Danlos syndrome.Annals of medicine and surgery (2012) · 2026Article
- Integrated metabolomics and machine learning identify predictive biomarkers via SHAP analysis for sintilimab-induced rash in lung cancer patients.Frontiers in pharmacology · 2026Article
- Targeting the Oral Mucosa: Emerging Drug Delivery Platforms and the Therapeutic Potential of Glycosaminoglycans.Pharmaceutics · 2025Review
- Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis.Journal of nanobiotechnology · 2025Review
- Viral infection and antiviral immunity in the oral cavity.Nature reviews. Immunology · 2025Review
- Buccal Absorption of Biopharmaceutics Classification System III Drugs: Formulation Approaches and Mechanistic Insights.Pharmaceutics · 2024Review
- Clinical Outcomes After Dental Surgery with Two Antiseptic Protocols.Dentistry journal · 2024Article
- Early intervention with oral mucosal barrier Protective agents in chronic oral graft-versus-host disease: a retrospective cohort study.BMC oral health · 2024Article
- Simulating the Skin Permeation Process of Ionizable Molecules.Journal of chemical information and modeling · 2024Article
- Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D.International journal of molecular sciences · 2024Review
- Effect of tobacco use on cadmium accumulation in the oral keratinized mucosa.BMC oral health · 2024Article
- A Synthetic Model of the Mucosa for Oral Penetration Studies.Membranes · 2023Article
- Permeation Protection by Waterproofing Mucosal Membranes.Pharmaceutics · 2023Article
- Engineering pedicled vascularized bladder tissue for functional bladder defect repair.Bioengineering & translational medicine · 2023Article
- The expanding organelle lipidomes: current knowledge and challenges.Cellular and molecular life sciences : CMLS · 2023Review
- Natural Ingredients of Transdermal Drug Delivery Systems as Permeation Enhancers of Active Substances through theMolecular pharmaceutics · 2023Review
- Oral Mucosa Models to Evaluate Drug Permeability.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin's permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10-20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.