Evidence map›Paper›PMID 34063322›Full record

ArticleNutrients2021

Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo

Alma Martelli, Lorenzo Flori, Era Gorica, Eugenia Piragine, Anella Saviano, Giuseppe Annunziata, Matteo Nicola Dario Di Minno, Roberto Ciampaglia, Ilenia Calcaterra, Francesco Maione and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. L-Arginine and TaurisoloInternational journal of molecular sciences · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Anti-Inflammatory Effect of the Natural HInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Alma MartelliDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-2090-7107
Lorenzo FloriDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Era GoricaDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Eugenia PiragineDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0001-6558-3065
Anella SavianoImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Giuseppe AnnunziataDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-1922-662X
Matteo Nicola Dario Di MinnoDepartment of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-8059-3819
Roberto CiampagliaDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Ilenia CalcaterraDepartment of Clinic Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-8077-2809
Francesco MaioneImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0003-2280-4299
Gian Carlo TenoreDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-0251-9936
Ettore NovellinoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
University of Naples Federico II · ITUniversity of Pisa · IT

Funding

NGN s.r.l. grant Proprietà vaso-protettive, vasorilascianti ed anti-ipertensive del nutraceutico Taurisolo" 32/2019
6 · The paper itself

Abstract

Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide biosynthesis, which is prodromic of hypertension and hypercoagulability. In this panorama, the nutraceutical supplement Taurisolo

Indexed as

Dietary SupplementsAMP-Activated Protein KinasesAnimalsAnticoagulantsAntihypertensive AgentsCatechinCells, CulturedCell SurvivalDisease Models, AnimalEndothelium, VascularHumansHypertensionMaleOxidative StressPlant ExtractsPolyphenolsAMP-Activated Protein KinasesAnticoagulantsAntihypertensive AgentsCatechinPlant ExtractsPolyphenolsProanthocyanidinsSirtuinsVasodilator AgentsAMPKendothelial dysfunctionhypertensionnitric oxidenutraceutical supplementpolyphenolic extractsirtuinsTaurisolo®vascular protection

Identifiers

PMID34063322
PMCPMC8147644
OpenAlexW3157920701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.