Evidence map›Paper›PMID 34063273›Full record

ArticleNutrients2021

Risk of Iron Overload in Obesity and Implications in Metabolic Health.

Aoibhín Moore Heslin, Aisling O'Donnell, Maria Buffini, Anne P Nugent, Janette Walton, Albert Flynn, Breige A McNulty

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Aoibhín Moore HeslinUCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.ORCID 0000-0001-6257-4083
Aisling O'DonnellUCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
Maria BuffiniUCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
Anne P NugentUCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-0206-1320
Janette WaltonDepartment of Biological Sciences, Munster Technological University, T12 P928 Cork, Ireland.ORCID 0000-0003-4758-5328
Albert FlynnSchool of Food & Nutritional Sciences, University College Cork, T12 K8AF Cork, Ireland.ORCID 0000-0002-7072-4202
Breige A McNultyUCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.ORCID 0000-0003-0841-063X
University College Dublin · IEMunster Technological University · IEUniversity College Cork · IE

Funding

Irish Department of Agriculture, Food and the Marine and the Health Research Board 15/F/673
6 · The paper itself

Abstract

Excessive adiposity is associated with several metabolic perturbations including disturbances in iron homeostasis. Increased systemic inflammation in obesity stimulates expression of the iron regulatory hormone hepcidin, which can result in a maldistribution of bodily iron, which may be implicated in metabolic dysfunction. This study aimed to investigate the effect of adiposity and any associated inflammation on iron homeostasis and the potential implications of dysregulated iron metabolism on metabolic health. Analyses are based on a subsample from the cross-sectional Irish National Adult Nutrition Survey (2008-2010) (

Indexed as

AdipokinesAdiposityAdultBiomarkersBlood GlucoseBody CompositionCardiometabolic Risk FactorsCross-Sectional StudiesFemaleFerritinsHepcidinsHomeostasisHumansInflammationIrelandIron OverloadAdipokinesBiomarkersBlood GlucoseFerritinsHepcidinsTriglyceridesbody fatferritinhepcidininflammationiron overloadmetabolic health

Identifiers

PMID34063273
PMCPMC8147503
OpenAlexW3158898510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.