Evidence map›Paper›PMID 34063233›Full record

ArticleCells2021

The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of

Katarzyna Lipska, Agata Filip, Anna Gumieniczek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katarzyna LipskaDepartment of Medicinal Chemistry, Medical University of Lublin, 20-090 Lublin, Poland.
Agata FilipDepartment of Cancer Genetics with Cytogenetics Laboratory, Medical University of Lublin, 20-080 Lublin, Poland.ORCID 0000-0001-7591-5887
Anna GumieniczekDepartment of Medicinal Chemistry, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0002-2503-5272
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant cells in chronic lymphocytic leukemia (CLL) show resistance to apoptosis, as well as to chemotherapy, which are related to deletions or mutations of

Indexed as

Gene Expression Regulation, LeukemicAgedAged, 80 and overApoptosisCell SurvivalChlorambucilCyclin-Dependent Kinase Inhibitor p21CytogeneticsFemaleGene Expression ProfilingHumansLeukemia, Lymphocytic, Chronic, B-CellLeukocytes, MononuclearMaleMiddle AgedMyeloid Cell Leukemia Sequence 1 ProteinBCL2 protein, humanCDKN1A protein, humanChlorambucilCyclin-Dependent Kinase Inhibitor p21MCL1 protein, humanMDM2 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Valproic Acidapoptosischlorambucil and valproic acidchronic lymphocytic leukemiacytogenetic prognosticsT53 and Bcl-2 family genes

Identifiers

PMID34063233
PMCPMC8147495
OpenAlexW3157859639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.