ArticleBrain sciences2021
Differential Alterations in Resting State Functional Connectivity Associated with Depressive Symptoms and Early Life Adversity.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Right anterior supramarginal gyrus-cerebellum hyperconnectivity and rumination partially mediate the link between childhood abuse and anger in late-life depression.Journal of affective disorders · 2026Article
- Adverse childhood experiences and post-traumatic stress impacts on brain connectivity and alcohol use in adolescence.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation.Translational psychiatry · 2025Article
- From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability.Frontiers in psychiatry · 2025Review
- Article
- Classification accuracy of structural and functional connectomes across different depressive phenotypes.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Disrupted resting-sate brain network dynamics in children born extremely preterm.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A Cross-Sectional Study: Structural and Related Functional Connectivity Changes in the Brain: Stigmata of Adverse Parenting in Patients with Major Depressive Disorder?Brain sciences · 2023Article
- Machine Learning Techniques Reveal Aberrated Multidimensional EEG Characteristics in Patients with Depression.Brain sciences · 2023Article
- The relationship between childhood emotional neglect experience and depressive symptoms and prefrontal resting functional connections in college students: The mediating role of reappraisal strategy.Frontiers in behavioral neuroscience · 2023Article
- The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults.European journal of psychotraumatology · 2023Article
- Contrasting Frontoparietal Network Connectivity in Antipsychotic Medication-Naive First-Episode Psychosis Patients Who Do and Do Not Display Features of the Deficit Syndrome.Schizophrenia bulletin · 2022Article
- Triple Network Functional Connectivity During Acute Stress in Adolescents and the Influence of Polyvictimization.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Brain Networks Involved in Depression in Patients with Frontotemporal Dementia and Parkinson's Disease: An Exploratory Resting-State Functional Connectivity MRI Study.Diagnostics (Basel, Switzerland) · 2022Article
- Self-prioritization is supported by interactions between large-scale brain networks.The European journal of neuroscience · 2022Article
- Neural functional connectivity during rumination in individuals with adverse childhood experiences.European journal of psychotraumatology · 2022Article
- Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.Frontiers in psychology · 2022Article
- Neural Connectivity Underlying Reward and Emotion-Related Processing: Evidence From a Large-Scale Network Analysis.Frontiers in systems neuroscience · 2022Article
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8 authors.
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Abstract
Depression and early life adversity (ELA) are associated with aberrant resting state functional connectivity (FC) of the default mode (DMN), salience (SN), and central executive networks (CEN). However, the specific and differential associations of depression and ELA with FC of these networks remain unclear. Applying a dimensional approach, here we analyzed associations of FC between major nodes of the DMN, SN, and CEN with severity of depressive symptoms and ELA defined as childhood abuse and neglect in a sample of 83 healthy and depressed subjects. Depressive symptoms were linked to increased FC within the SN and decreased FC of the SN with the DMN and CEN. Childhood abuse was associated with increased FC within the SN, whereas childhood neglect was associated with decreased FC within the SN and increased FC between the SN and the DMN. Our study thus provides evidence for differential associations of depressive symptoms and ELA with resting state FC and contributes to a clarification of previously contradictory findings. Specific FC abnormalities may underlie specific cognitive and emotional impairments. Future research should link specific clinical symptoms resulting from ELA to FC patterns thereby characterizing depression subtypes with specific neurobiological signatures.
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