Evidence map›Paper›PMID 34063120›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

A Skin Cancer Prophylaxis Study in Hairless Mice Using Methylene Blue, Riboflavin, and Methyl Aminolevulinate as Photosensitizing Agents in Photodynamic Therapy.

Hans Christian Wulf, Rami Nabil Al-Chaer, Martin Glud, Peter Alshede Philipsen, Catharina Margrethe Lerche

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Glyphosate exposure did not increase the risk of UVR-induced skin tumors in hairless mice.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  3. Repeated exposure to fractional COLasers in surgery and medicine · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hans Christian WulfDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.
Rami Nabil Al-ChaerDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.ORCID 0000-0002-0348-6734
Martin GludDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.
Peter Alshede PhilipsenDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.ORCID 0000-0002-9656-733X
Catharina Margrethe LercheDepartment of Dermatology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.ORCID 0000-0003-3653-6424
Bispebjerg Hospital · DKUniversity of Copenhagen · DK

Funding

Kgl. Hofbundtmager Aage Bangs Fond no 47
6 · The paper itself

Abstract

The high incidence of sunlight-induced human skin cancers reveals a need for more effective photosensitizing agents. In this study, we compared the efficacy of prophylactic photodynamic therapy (PDT) when methylene blue (MB), riboflavin (RF), or methyl aminolevulinate (MAL) were used as photosensitizers. All mice in four groups of female C3.Cg/TifBomTac hairless immunocompetent mice (

Indexed as

hairless micemethyl aminolevulinatemethylene bluePDTphotosensitizing agentsprophylactic treatmentriboflavinskin tumorsultraviolet radiation

Identifiers

PMID34063120
PMCPMC8148192
OpenAlexW3157310004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.