Evidence map›Paper›PMID 34063086›Full record

ReviewInternational journal of molecular sciences2021

Preventive Applications of Polyphenols in Dentistry-A Review.

Jasmin Flemming, Clara Theres Meyer-Probst, Karl Speer, Isabelle Kölling-Speer, Christian Hannig, Matthias Hannig

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Article
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  9. Article
  10. The effect of fruit extracts containing phenolic compounds on the survivability of Streptococcus mutans: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  11. Article
  12. Effects ofFrontiers in oral health · 2026
    Article
  13. Article
  14. Article
  15. Assessing the Impact of Vegan Toothpastes on Enamel Color Change and Surface Properties.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025
    Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jasmin FlemmingClinic of Operative Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
Clara Theres Meyer-ProbstClinic of Operative Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
Karl SpeerSpecial Food Chemistry and Food Production, TU Dresden, Bergstraße 66, D-01069 Dresden, Germany.ORCID 0000-0001-6576-1108
Isabelle Kölling-SpeerSpecial Food Chemistry and Food Production, TU Dresden, Bergstraße 66, D-01069 Dresden, Germany.
Christian HannigClinic of Operative Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
Matthias HannigClinic of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital, Saarland University, Building 73, D-66421 Homburg, Germany.

Funding

German Research Foundation DFG HA 2718/27-1; HA 5192/19-1 ; SP 464/6-1
6 · The paper itself

Abstract

Polyphenols are natural substances that have been shown to provide various health benefits. Antioxidant, anti-inflammatory, and anti-carcinogenic effects have been described. At the same time, they inhibit the actions of bacteria, viruses, and fungi. Thus, studies have also examined their effects within the oral cavity. This review provides an overview on the different polyphenols, and their structure and interactions with the tooth surface and the pellicle. In particular, the effects of various tea polyphenols on bioadhesion and erosion have been reviewed. The current research confirms that polyphenols can reduce the growth of cariogenic bacteria. Furthermore, they can decrease the adherence of bacteria to the tooth surface and improve the erosion-protective properties of the acquired enamel pellicle. Tea polyphenols, especially, have the potential to contribute to an oral health-related diet. However, in vitro studies have mainly been conducted. In situ studies and clinical studies need to be extended and supplemented in order to significantly contribute to additive prevention measures in caries prophylaxis.

Indexed as

DentistryAnimalsDental PellicleDietHumansMetabolic Networks and PathwaysPolyphenolsTeaPolyphenolsTeamedicinal plantsmolecular mechanismspolyphenolspreventive dentistrysalivary pellicletea drugstransmission electron microscopy (TEM)

Identifiers

PMID34063086
PMCPMC8124254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.