Evidence map›Paper›PMID 34063078›Full record

ReviewAntioxidants (Basel, Switzerland)2021

Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future.

Carla Iacobini, Martina Vitale, Carlo Pesce, Giuseppe Pugliese, Stefano Menini

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Carla IacobiniDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.
Martina VitaleDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.
Carlo PesceDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal Infantile Sciences (DINOGMI), Department of Excellence of MIUR, University of Genoa Medical School, 16132 Genoa, Italy.
Giuseppe PuglieseDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0003-1574-0397
Stefano MeniniDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0001-7328-2385
Sapienza University of Rome · ITUniversity of Genoa · IT

Funding

EFSD and Sanofi European Research Programme in Macrovascular Complications of Diabetes 2019 N/ASapienza Università di Roma N/A
6 · The paper itself

Abstract

Twenty years have passed since Brownlee and colleagues proposed a single unifying mechanism for diabetic complications, introducing a turning point in this field of research. For the first time, reactive oxygen species (ROS) were identified as the causal link between hyperglycemia and four seemingly independent pathways that are involved in the pathogenesis of diabetes-associated vascular disease. Before and after this milestone in diabetes research, hundreds of articles describe a role for ROS, but the failure of clinical trials to demonstrate antioxidant benefits and some recent experimental studies showing that ROS are dispensable for the pathogenesis of diabetic complications call for time to reflect. This twenty-year journey focuses on the most relevant literature regarding the main sources of ROS generation in diabetes and their role in the pathogenesis of cell dysfunction and diabetic complications. To identify future research directions, this review discusses the evidence in favor and against oxidative stress as an initial event in the cellular biochemical abnormalities induced by hyperglycemia. It also explores possible alternative mechanisms, including carbonyl stress and the Warburg effect, linking glucose and lipid excess, mitochondrial dysfunction, and the activation of alternative pathways of glucose metabolism leading to vascular cell injury and inflammation.

Indexed as

advanced glycation end-productsantioxidantsdiabeteshyperglycemiamethylglyoxalmitochondrial dysfunctionnuclear factor erythroid 2-related factor 2reactive carbonyl speciesreactive oxygen speciesWarburg effect

Identifiers

PMID34063078
PMCPMC8147954
OpenAlexW3158360048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.