Evidence map›Paper›PMID 34063003›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing.

Simarjot Kaur Sandhu, Suneel Kumar, Jayant Raut, Mandeep Singh, Sandeep Kaur, Garima Sharma, Tomas L Roldan, Sonia Trehan, Jennifer Holloway, Gabriella Wahler and 7 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  4. Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Simarjot Kaur SandhuInstitute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Suneel KumarDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-4829-8654
Jayant RautInstitute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Mandeep SinghInstitute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Sandeep KaurInstitute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Garima SharmaInstitute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Tomas L RoldanDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0001-7950-7696
Sonia TrehanCenter for Dermal Research (CDR), Life Sciences Building, Rutgers University, Piscataway, NJ 08854, USA.
Jennifer HollowayDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Gabriella WahlerCounter ACT Center of Excellence, Rutgers University, Piscataway, NJ 08854, USA.
Jeffrey D LaskinCounter ACT Center of Excellence, Rutgers University, Piscataway, NJ 08854, USA.
Patrick J SinkoDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-0157-1895
Francois BerthiaumeDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Bozena Michniak-KohnDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Praveen RishiDepartment of Microbiology, Panjab University, Chandigarh 160014, India.
Narayanan GaneshJawaharlal Nehru Cancer Hospital & Research Centre, Bhopal 462001, India.
Indu Pal KaurInstitute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Rutgers, The State University of New Jersey · USPanjab University · INJawaharlal Nehru Cancer Hospital and Research Centre · IN

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Countermeasures Against Chemical Threats NIH grant #U54AR055073NIEHS NIH HHS P30 ES005022NIEHS NIH HHS T32 ES007148University Grant Commission under UGC- RFMS F.4-1/2006 (BSR)/5-94/2007 (BSR)
6 · The paper itself

Abstract

The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid lipid nanoparticles (CSLNs) for wound healing. CSLNs prepared by hot, high-pressure homogenization, without using organic solvents, were optimized using the Taguchi design followed by the central composite design. The optimized CSLNs exhibited a high assay/drug content (0.6%

Indexed as

biofilmnanocarriersoxidative stresssafetyTNFαVEGFwound closure

Identifiers

PMID34063003
PMCPMC8148018
OpenAlexW3159102391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.