Evidence map›Paper›PMID 34062974›Full record

ArticleTomography (Ann Arbor, Mich.)2021

Evaluation of Amyotrophic Lateral Sclerosis-Induced Muscle Degeneration Using Magnetic Resonance-Based Relaxivity Contrast Imaging (RCI).

Sudarshan Ragunathan, Laura C Bell, Natenael Semmineh, Ashley M Stokes, Jeremy M Shefner, Robert Bowser, Shafeeq Ladha, C Chad Quarles

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sudarshan RagunathanBarrow Neuroimaging Innovation Center, Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ 85013, USA.ORCID 0000-0002-2871-1758
Laura C BellBarrow Neuroimaging Innovation Center, Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ 85013, USA.ORCID 0000-0001-8164-8324
Natenael SemminehBarrow Neuroimaging Innovation Center, Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Ashley M StokesBarrow Neuroimaging Innovation Center, Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ 85013, USA.ORCID 0000-0003-1137-5003
Jeremy M ShefnerDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Robert BowserDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA.ORCID 0000-0001-5404-7259
Shafeeq LadhaGregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
C Chad QuarlesBarrow Neuroimaging Innovation Center, Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Barrow Neurological Institute · US

Funding

Amyotrophic Lateral Sclerosis Association 8032198Flinn Foundation 2094Fulton Family Foundation 3032285
6 · The paper itself

Abstract

(1) Background: This work characterizes the sensitivity of magnetic resonance-based Relaxivity Contrast Imaging (RCI) to Amyotrophic Lateral Sclerosis (ALS)-induced changes in myofiber microstructure. Transverse Relaxivity at Tracer Equilibrium (TRATE), an RCI-based parameter, was evaluated in the lower extremities of ALS patients and healthy subjects. (2) Methods: In this IRB-approved study, 23 subjects (12 ALS patients and 11 healthy controls) were scanned at 3T (Philips, The Netherlands). RCI data were obtained during injection of a gadolinium-based contrast agent. TRATE, fat fraction and T

Indexed as

Amyotrophic Lateral SclerosisHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMuscle, SkeletalNetherlandsALSmuscle myofiberperfusion MRIrelaxivity contrast imagingTRATE

Identifiers

PMID34062974
PMCPMC8162571
OpenAlexW3159334970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.