Evidence map›Paper›PMID 34062954›Full record

ArticleBiology2021

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (

Weiwei Liu, Yan Cao, Yue Lin, Keai Sinn Tan, Haishan Zhao, Haihua Guo, Wen Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Emerging significance of butyrylcholinesterase.World journal of experimental medicine · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Weiwei LiuInstitute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.ORCID 0000-0002-4003-1915
Yan CaoYZ Health-tech Inc., Hengqin District, Zhuhai 519000, China.
Yue LinInstitute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Keai Sinn TanYZ Health-tech Inc., Hengqin District, Zhuhai 519000, China.ORCID 0000-0001-6649-3424
Haishan ZhaoInstitute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Haihua GuoInstitute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Wen TanInstitute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Guangdong University of Technology · CNJinan University · CNMonash University Malaysia · MY

Funding

The Biomedical Research Institute of Guangdong University of Technology 1182/220418110The Biomedicine International Technology Transfer Center of Foshan High-tech Zone 1182/503170031
6 · The paper itself

Abstract

Butyrylcholinesterase (BChE) is detected in plaques preferentially in Alzheimer's disease (AD) and may be associated with stress disorders. However, the physiological function of BChE in the central nervous system remains to be further investigated. BChE knockout (KO) mice and wild-type (WT) mice with orally or intranasal administration of (

Indexed as

butyrylcholinesterasecognitive declinefear extinction memory(R)-bambuterol

Identifiers

PMID34062954
PMCPMC8147965
OpenAlexW3159437694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.