Evidence map›Paper›PMID 34062873›Full record

ArticlePharmaceutics2021

Development of In Situ Gelling Meloxicam-Human Serum Albumin Nanoparticle Formulation for Nose-to-Brain Application.

Gábor Katona, Bence Sipos, Mária Budai-Szűcs, György Tibor Balogh, Szilvia Veszelka, Ilona Gróf, Mária A Deli, Balázs Volk, Piroska Szabó-Révész, Ildikó Csóka

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gábor KatonaInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary.ORCID 0000-0003-1564-4813
Bence SiposInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary.ORCID 0000-0002-0131-4728
Mária Budai-SzűcsInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary.ORCID 0000-0001-5187-5702
György Tibor BaloghDepartment of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary.
Szilvia VeszelkaBiological Research Centre, Institute of Biophysics, Temesvári Blvd. 62, H-6726 Szeged, Hungary.
Ilona GrófBiological Research Centre, Institute of Biophysics, Temesvári Blvd. 62, H-6726 Szeged, Hungary.
Mária A DeliBiological Research Centre, Institute of Biophysics, Temesvári Blvd. 62, H-6726 Szeged, Hungary.ORCID 0000-0001-6084-6524
Balázs VolkEgis Pharmaceuticals Plc., Keresztúri Str. 30-38, H-1106 Budapest, Hungary.ORCID 0000-0002-2019-1874
Piroska Szabó-RévészInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary.ORCID 0000-0002-5336-6052
Ildikó CsókaInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary.ORCID 0000-0003-0807-2781
University of Szeged · HUHUN-REN Szegedi Biológiai Kutatóközpont · HUEgis Pharmaceuticals (Hungary) · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered in liquid state into the nostril, and to increase the resistance of the formulation against mucociliary clearance by sol-gel transition on the nasal mucosa, as well as to improve drug absorption. Nanoparticle characterization showed that formulations containing 12-15%

Indexed as

brain PAMPAmuco-adhesionquality by designrapid equilibrium dialysisRPMI 2650 nasal epithelial cell

Identifiers

PMID34062873
PMCPMC8147280
OpenAlexW3159083690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.