ArticleGenes2021
miRNA Profiling in the Chicken Liver under the Influence of Early Microbiota Stimulation with Probiotic, Prebiotic, and Synbiotic.
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Edible Plant-Derived Exosome-like Nanoparticles as Prebiotic Nanocarriers: Gut Microbiota Modulation and Functional Food Potential.Pharmaceutics · 2026Review
- Host genetic and environmental determinants of chicken gut microbiota: A review.Poultry science · 2026Review
- Microbial modulators of the epigenome: probiotic regulation of MiRNAs and LncRNAs in health and disease and preventive medicine.Gut pathogens · 2026Review
- Effects of in ovo stimulation with potential epigenetic modulators on immune system phenotype across three generations in a chicken model.Scientific reports · 2025Article
- Embryonic Thermal Manipulation Affects Body Performance Parameters and Cecum Microbiome in Broiler Chickens in Response to Post-Hatch Chronic Heat Stress Challenge.Animals : an open access journal from MDPI · 2025Article
- Effects of Embryonic Thermal Manipulation on Body Performance and Cecum Microbiome in Broiler Chickens Following a Post-Hatch Lipopolysaccharide Challenge.Animals : an open access journal from MDPI · 2025Article
- Modulation of gene expression in immune-related organs by in ovo stimulation with probiotics and prophybiotics in broiler chickens.Journal of applied genetics · 2025Article
- Predisposition factors and control strategies of avian pathogenicFrontiers in veterinary science · 2024Review
- Changes in the gene expression and methylation in chicken cecal tonsils after in ovo administration of bioactive substances.Scientific reports · 2023Article
- MicroRNA expression in immune tissues of adult chickens after embryo stimulation with bioactive substances.Scientific reports · 2023Article
- MiRNA-Seq reveals key MicroRNAs involved in fat metabolism of sheep liver.Frontiers in genetics · 2023Article
- Physiological effects ofFrontiers in veterinary science · 2023Review
- Pre-hatching and post-hatching environmental factors related to epigenetic mechanisms in poultry.Journal of animal science · 2022Review
- Managing Gut Microbiota through In Ovo Nutrition Influences Early-Life Programming in Broiler Chickens.Animals : an open access journal from MDPI · 2021Review
- Epigenetic changes in poultry due to reprogramming of the gut microbiota.Animal frontiers : the review magazine of animal agriculture · 2021Article
- Identification of microRNAs in Silver Carp (Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic regulation of gene expression is a form of interaction of the external environment on reading and transcription of genetic information encoded in nucleic acids. We provided evidence that early stimulation of the chicken microbiota with in ovo delivered synbiotics influenced gene expression and DNA methylation in the liver. Therefore, we hypothesize that the stimulation of microbiota by administering bioactive substances in ovo also affects the activity of miRNA in liver. For the analysis of miRNA activity, RNA was isolated from liver of adult broiler chicken and native chicken breed. The animals received a prebiotic, probiotic and synbiotic in ovo on day 12 of egg incubation. The analysis of miRNA expression was performed using the LNA method on a miRNA panel selected on the basis of previous microarray experiments. We have found increased miRNA expression activity after probiotic and synbiotic administration, especially in native chicken breed. Our results suggest that prebiotics reduce or do not affect miRNA activity. We have also shown that miRNA activity is regulated by the substance and genotype of the chicken. We can conclude that miRNAs constitute an important component of the molecular mechanism of host-probiotic interaction in liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.