Evidence map›Paper›PMID 34062864›Full record

ArticleJournal of clinical medicine2021

Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry.

Francesco Giuseppe De Rosa, Annagloria Palazzo, Tiziana Rosso, Nour Shbaklo, Marco Mussa, Lucio Boglione, Enrica Borgogno, Antonella Rossati, Simone Mornese Pinna, Silvia Scabini and 10 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Microorganisms · 2023
    Article
  5. Article
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  7. Mortality trends and length of stays among hospitalized patients with COVID-19 in Ontario and Québec (Canada): a population-based cohort study of the first three epidemic waves.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Francesco Giuseppe De RosaDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-8338-0130
Annagloria PalazzoDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
Tiziana RossoUnit of Clinical Epidemiology, CPO, AOU "Città della Salute e della Scienza", 10126 Turin, Italy.
Nour ShbakloDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-0171-9274
Marco MussaInfectious Diseases Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0002-0330-4427
Lucio BoglioneDepartment of Translational Medicine, University of Eastern Piedmont, 13100 Novara, Italy.
Enrica BorgognoInfectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy.
Antonella RossatiInfectious Diseases Department, University Hospital "Maggiore della Carità", 28100 Novara, Italy.
Simone Mornese PinnaDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
Silvia ScabiniDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
Guido ChichinoInfectious Diseases Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Silvio BorrèUnit of Infectious Diseases, Saint Andrea Hospital, 13100 Vercelli, Italy.
Valerio Del BonoInfectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy.
Pietro Luigi GaravelliInfectious Diseases Department, University Hospital "Maggiore della Carità", 28100 Novara, Italy.
Diego BarillàHospital Pharmacy, Città della Salute e della Scienza, 10126 Turin, Italy.
Francesco CattelHospital Pharmacy, Città della Salute e della Scienza, 10126 Turin, Italy.
Giovanni Di PerriDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
Giovannino CicconeUnit of Clinical Epidemiology, CPO, AOU "Città della Salute e della Scienza", 10126 Turin, Italy.
Tommaso LupiaInfectious Diseases Unit, Cardinal Massaia Hospital, 14100 Asti, Italy.ORCID 0000-0002-3865-9519
Silvia CorcioneDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
University of Turin · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITAzienda Sanitaria Locale di Asti · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITCTO Andrea Alesini · ITTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCORACLE is a retrospective and prospective, regional multicenter registry, developed to evaluate risk factors for mortality in a cohort of patients admitted with SARS-CoV-2 infection within non-intensive wards.

methodsThe primary objective was to estimate the role of several prognostic factors on hospital mortality in terms of adjusted Odds Ratios (aOR) with multivariable logistic regression models.

resultsA total of 1538 patients were enrolled; 42% were female, and 58% were >70 years old. Deceased patients were 422 (27%), with a median age of 83 years (IQR (Inter Quartile Range) 76-87). Older age at admission (aOR 1.07 per year, 95%CI 1.06-1.09), diabetes (1.41, 1.02-1.94), cardiovascular disease (1.79, 1.31-2.44), immunosuppression (1.65, 1.04-2.62), estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m

conclusionsSeveral risk factors were associated with mortality in SARS-CoV-2 positive patients. Although HCQ seems to be the only factor significantly associated with reduced mortality, this result is in contrast with evidence from randomized studies. These results should be interpreted in light of the study limitations.

Indexed as

COVID-19hydroxichloroquinemortalitypneumoniaSARS-CoV-2

Identifiers

PMID34062864
PMCPMC8124506
OpenAlexW3157165331

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.