ArticleJournal of clinical laboratory analysis2021
Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Metabolic syndrome components individually worsen the outcome of acute pancreatitis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Clinical usefulness of scoring systems to predict severe acute pancreatitis: A systematic review and meta-analysis with pre and post-test probability assessment.United European gastroenterology journal · 2023Pooled it
- First report on leucocytes cell population data as an applicable test for clinical stratification in people living with HIV.Virus research · 2026Article
- Article
- Association between the Fibrosis-4 index and mortality risk in acute pancreatitis.Frontiers in medicine · 2026Article
- The Analysis of the Clinical Course of Acute Pancreatitis in Children-A Single-Center Study.Children (Basel, Switzerland) · 2025Article
- Interleukin-6 and Leukocyte Cell Population Data in Newly Diagnosed Sepsis-A Prospective Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Assessment of point-of-care quantitative serum canine pancreatic lipase testing for diagnosing acute pancreatitis in dogs.Frontiers in veterinary science · 2025Article
- B Cells and Double-Negative B Cells (CD27Diseases (Basel, Switzerland) · 2024Article
- Review
- High-density lipoprotein cholesterol level as an independent protective factor against aggravation of acute pancreatitis: a case-control study.Frontiers in endocrinology · 2023Article
- The Role of Innate Immune Cells in the Prediction of Early Renal Allograft Injury Following Kidney Transplantation.Journal of clinical medicine · 2022Article
- Correlation of Different Serum Biomarkers with Prediction of Early Pancreatic Graft Dysfunction Following Simultaneous Pancreas and Kidney Transplantation.Journal of clinical medicine · 2022Article
- Analysis of the Application Value of Echocardiography Combined with CK-MB, Alb, and CysC in the Prognosis Assessment of Patients with Chronic HF.Contrast media & molecular imaging · 2022Article
- Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prediction for severe acute pancreatitis (SAP) is the key to give timely targeted treatment. Leukocyte cell population data (CPD) have been widely applied in early prediction and diagnosis of many diseases, but their predictive ability for SAP remains unexplored. We aim to testify whether CPD could be an indicator of AP severity in the early stage of the disease.
methodsThe prospective observational study was conducted in the emergency department ward of a territory hospital in Shanghai. The enrolled AP patients should meet 2012 Atlanta guideline.
resultsTotally, 103 AP patients and 62 healthy controls were enrolled and patients were classified into mild AP (n = 30), moderate SAP (n = 42), and SAP (n = 31). Forty-two CPD parameters were examined in first 3 days of admission. Four CPD parameters were highest in SAP on admission and were constantly different among 3 groups during first 3 days of hospital stay. Eighteen CPD parameters were found correlated with the occurrence of SAP. Stepwise multivariate logistic regression analysis identified a scoring system of 4 parameters (SD_LALS_NE, MN_LALS_LY, SD_LMALS_MO, and SD_AL2_MO) with a sensitivity of 96.8%, specificity of 65.3%, and AUC of 0.87 for diagnostic accuracy on early identification of SAP. AUC of this scoring system was comparable with MCTSI, SOFA, APACHE II, MMS, BISAP, or biomarkers as CRP, PCT, and WBC in prediction of SAP and ICU transfer or death.
conclusionsSeveral leukocyte CPD parameters have been identified different among MAP, MSAP, and SAP. They might be ultimately incorporated into a predictive system marker for severity of AP.
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