Evidence map›Paper›PMID 34062290›Full record

ArticleDomestic animal endocrinology2021

Maternal nutrient restriction alters thyroid hormone dynamics in placentae of sheep having small for gestational age fetuses.

C B Steinhauser, K Askelson, K C Hobbs, F W Bazer, M C Satterfield

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PubMed Full text at PMC Publisher
In one paragraph

Article in Domestic animal endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C B SteinhauserDepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, Texas 77843.
K AskelsonDepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, Texas 77843.
K C HobbsDepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, Texas 77843.
F W BazerDepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, Texas 77843.
M C SatterfieldDepartment of Animal Science, Texas A&M University, 2471 TAMU, College Station, Texas 77843. Electronic address: csatterfield@tamu.edu.
Texas A&M University · US

Funding

Understanding Placental Adaptation to Maternal MalnutritionR01HD080658 · NICHD · TEXAS A&M AGRILIFE RESEARCH · PI SATTERFIELD, MICHAEL CAREY · 2015 to 2019
$1.5M
NICHD NIH HHS R01 HD080658
6 · The paper itself

Abstract

Thyroid hormones regulate a multitude of metabolic and cellular processes involved in placental and fetal growth, while maternal nutrient restriction (NR) has the potential to influence these processes. Those fetuses most impacted by NR, as categorized by weight, are termed small for gestational age (SGA), but the role of thyroid hormones in these pregnancies is not fully understood. Therefore, the aims of the present study were to determine effects of NR during pregnancy on maternal and fetal thyroid hormone concentrations, as well as temporal and cell-specific expression of mRNAs and proteins for placental thyroid hormone transporters, thyroid hormone receptors, and deiodinases in ewes having either SGA or normal weight fetuses. Ewes with singleton pregnancies were fed either a 100% NRC (n = 8) or 50% NRC (NR; n = 28) diet from Days 35 to 135 of pregnancy with a single placentome surgically collected on Day 70. Fetal weight at necropsy on Day 135 was used to designate the fetuses as NR NonSGA (n = 7; heaviest NR fetuses) or NR SGA (n = 7; lightest NR fetuses). Thyroid hormone levels were lower in NR SGA compared to NR NonSGA ewes, while all NR fetuses had lower concentrations of thyroxine at Day 135. Expression of mRNAs for thyroid hormone transporters SLC16A2, SLC16A10, SLCO1C1, and SLCO4A1 were altered by day, but not nutrient restriction. Expression of THRA mRNA and protein was dysregulated in NR SGA fetuses with protein localized to syncytial and stromal cells in placentomes in all groups. The ratio of deiodinases DIO2 and DIO3 was greater for NR SGA placentae at Day 70, while DIO3 protein was less abundant in placentae from NR SGA than 100% NRC ewes. These results identify mid-gestational modifications in thyroid hormone-associated proteins in placentomes of ewes having SGA fetuses, as well as a potential for placentomes from NonSGA pregnancies to adapt to, and overcome, nutritional restrictions during pregnancy.

Indexed as

Animal Nutritional Physiological PhenomenaPlacentaAnimalsFemaleFetusGestational AgeNutrientsPregnancySheepThyroid HormonesNutrientsThyroid HormonesDeiodinasePlacentaPregnancySmall for gestational ageThyroid hormoneThyroid hormone receptor

Identifiers

PMID34062290
PMCPMC8380679
OpenAlexW3157272653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.