ArticleJournal of the Royal Society, Interface2021
A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Placental Blood-Flow Velocity Quantification From Diffusion MRI.Magnetic resonance in medicine · 2026Article
- Multiscale computational modeling to quantify how spiral artery remodeling alters wall shear stress on placental villi.PLoS computational biology · 2026Article
- Modelling maternal cardiovascular adaptation to pregnancy: a scoping review.BMC pregnancy and childbirth · 2025Article
- Bioprinted Scaffolds for Biomimetic Applications: A State-of-the-Art Technology.Biomimetics (Basel, Switzerland) · 2025Review
- Bioengineering approaches for patient-specific analysis of placenta structure and function.Placenta · 2025Article
- High-resolution X-ray phase-contrast tomography of human placenta with different wavefront markers.Scientific reports · 2025Article
- 3D multiscale characterization of the human placenta: Bridging anatomy and histology by X-ray phase-contrast tomography.PNAS nexus · 2025Article
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- A Comprehensive Study on the Diagnostic Value of Multi-Slice Computed Tomography for Peripancreatic Infection in Elderly With Severe Acute Pancreatitis.Gastroenterology research · 2024Article
- Multi-scale Modelling of Shear Stress on the Syncytiotrophoblast: Could Maternal Blood Flow Impact Placental Function Across Gestation?Annals of biomedical engineering · 2023Article
- Three-dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography.Bioengineering & translational medicine · 2023Article
- Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media.Interface focus · 2022Article
- SuRVoS 2: Accelerating Annotation and Segmentation for Large Volumetric Bioimage Workflows Across Modalities and Scales.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Multi-scale structural assessment of biological soft tissue is challenging but essential to gain insight into structure-function relationships of tissue/organ. Using the human placenta as an example, this study brings together sophisticated sample preparation protocols, advanced imaging and robust, validated machine-learning segmentation techniques to provide the first massively multi-scale and multi-domain information that enables detailed morphological and functional analyses of both maternal and fetal placental domains. Finally, we quantify the scale-dependent error in morphological metrics of heterogeneous placental tissue, estimating the minimal tissue scale needed in extracting meaningful biological data. The developed protocol is beneficial for high-throughput investigation of structure-function relationships in both normal and diseased placentas, allowing us to optimize therapeutic approaches for pathological pregnancies. In addition, the methodology presented is applicable in the characterization of tissue architecture and physiological behaviours of other complex organs with similarity to the placenta, where an exchange barrier possesses circulating vascular and avascular fluid spaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.