Evidence map›Paper›PMID 34061977›Full record

ArticleComprehensive Physiology2021

Uterine Vascular Control Preconception and During Pregnancy.

Sara B Fournier, Jeanine N D'Errico, Phoebe A Stapleton

Open access · greenAbstract read
In one paragraph

Article in Comprehensive Physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. The Application of Engineered Nanomaterials in Perinatal Therapeutics.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  17. Observational
  18. Perivascular Adipose Tissue and Uterine Artery Adaptations to Pregnancy.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sara B FournierEnvironmental and Occupational Health Sciences Institute, Piscataway, New Jersey, USA.
Jeanine N D'ErricoDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA.
Phoebe A StapletonEnvironmental and Occupational Health Sciences Institute, Piscataway, New Jersey, USA.
Rutgers, The State University of New Jersey · USEnvironmental and Occupational Health Sciences Institute · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Microvascular mechanisms of growth restriction after environmental toxicant exposureR01ES031285 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI STAPLETON, PHOEBE · 2021 to 2025
$3.5M
Mitochondrial Mechanisms, Microvascular Function, and Gestational NanotoxicologyR00ES024783 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI STAPLETON, PHOEBE · 2017 to 2019
$747k
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R00 ES024783NIEHS NIH HHS R01 ES031285NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

Successful pregnancy and reproduction are dependent on adequate uterine blood flow, placental perfusion, and vascular responsivity to fetal demands. The ability to support pregnancy centers on systemic adaptation and endometrial preparation through decidualization, embryonic implantation, trophoblast invasion, arterial/arteriolar reactivity, and vascular remodeling. These adaptations occur through responsiveness to endocrine signaling and local uteroplacental mediators. The purpose of this article is to highlight the current knowledge associated with vascular remodeling and responsivity during uterine preparation for and during pregnancy. We focus on maternal cardiovascular systemic and uterine modifications, endometrial decidualization, implantation and invasion, uterine and spiral artery remodeling, local uterine regulatory mechanisms, placentation, and pathological consequences of vascular dysfunction during pregnancy. © 2021 American Physiological Society. Compr Physiol 11:1-23, 2021.

Indexed as

PlacentaPlacentationFemaleHumansPlacental CirculationPregnancyTrophoblastsVascular Remodeling

Identifiers

PMID34061977
PMCPMC8485361
OpenAlexW3165362459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.