Evidence map›Paper›PMID 34061894›Full record

ArticlePloS one2021

Comparison of intravenous magnesium sulphate and lidocaine for attenuation of cardiovascular response to laryngoscopy and endotracheal intubation in elective surgical patients at Zewditu Memorial Hospital Addis Ababa, Ethiopia.

Abebaw Misganaw, Mulualem Sitote, Suliman Jemal, Eyayalem Melese, Metages Hune, Fetene Seyoum, Alekaw Sema, Dagim Bimrew

3 registry-linked trialsAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06516861 phase1completednot on this mapstarted 2024, after this paper: background citation

Comparison of Magnesium Sulphate 30 mg/Kg With Lidocaine 1,5 mg/Kg in Hemodynamic Changes and Cortisol Level Post-intubation in Patient Undergoing Craniotomy

TypeinterventionalSponsorArsil RadiansyahRan2024 to 2024Enrolled30ConditionsIntubation ComplicationArmsMagnesium Sulfate 20 MG/ML, Lidocaine IV, saline solution
NCT07089173 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effect-site Concentration of Remifentanil Blunting Endotracheal Intubation Responses During Anesthesia Induction With Lidocaine or Sufentanil Combined With Etomidate: A Randomized Controlled Study

TypeinterventionalSponsorPeking University Shenzhen HospitalRan2025 to 2026Enrolled99ConditionsHemodynamicsArmsIntravenous normal saline (NS 0.9), intravenous sufentanil, Intravenous lidocaine
NCT07258628 nacompletednot on this mapstarted 2025, after this paper: background citation

Magnesium and Fentanyl in Preventing Reflex Hemodynamic Response to Endotracheal Intubation in Patients Aged 50 Years and Older

TypeinterventionalSponsorAnkara City Hospital BilkentRan2025 to 2026Enrolled76ConditionsHypertension, TachycardiaArmsmagnesium sulfate, Fentanyl (IV)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abebaw MisganawDepartment of Anesthesia, School of Medicine, Debre Markos University, Debre Markos, Ethiopia.ORCID 0000-0002-5575-4817
Mulualem SitoteSchool of Anesthesia, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Suliman JemalSchool of Anesthesia, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Eyayalem MeleseSchool of Anesthesia, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-8469-9220
Metages HuneDepartment of Anesthesia, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Fetene SeyoumDepartment of Anesthesia, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia.
Alekaw SemaDepartment of Midwifery, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia.
Dagim BimrewDepartment of Anesthesia, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaryngoscopy and endotracheal intubation are essential components of general anesthesia. But it is always associated with side effects called reflex cardiovascular responses. Many methods have been identified to attenuate these responses like intravenous lidocaine, deep inhalational anesthesia, vasodilators, intravenous magnesium sulphate even though therapeutic superiority remains understudied.

methodsAn institutional-based cohort study on 112 adult patients aged between 18-60 years was applied. 37 patients in the non-exposed group (Group N), 37 in the lidocaine group (Group L), and 38 in magnesium sulphate (Group M) were included. The hemodynamic parameters like heart rate, systolic, diastolic and mean arterial blood pressure at various time points up to 7 minutes post-intubation were recorded and the effect of both drugs to reduce hemodynamic responses was compared. Parametric data were analyzed using ANOVA and nonparametric data using the Kuruska-Wallis H rank test. P-value < 0.05 considered statistically significant.

resultsIn all three groups, there was a statistically significant rise in heart rate and blood pressure from baseline. There was a statistically significant difference in mean heart rate throughout study minutes among the groups (p<0.001). However, there was no statistically significant difference in mean heart rate between Groups M and L at all post-intubation time intervals. In blood pressure at all three parameters there was statistically significant difference among groups at all-time points except no difference at 7th minutes in DBP. There was significantly lower blood pressure in group M compared to both groups.

conclusionIn conclusion, prophylactic administration of magnesium sulphate and lidocaine was effective in attenuating hemodynamic responses to the stress effect of laryngoscopy and intubation. But based on our finding prophylaxis of magnesium sulphate is associated with a more favorable hemodynamic response.

Indexed as

Administration, IntravenousAdolescentAdultAnesthetics, LocalArterial PressureElective Surgical ProceduresEthiopiaFemaleHeart RateHumansHypertensionIntubation, IntratrachealLaryngoscopyLidocaineMagnesium SulfateMaleAnesthetics, LocalLidocaineMagnesium Sulfate

Identifiers

PMID34061894
PMCPMC8168879

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.