ArticlePLoS genetics2021
An autoregulatory negative feedback loop controls thermomorphogenesis in Arabidopsis.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- The miR319/bHLH094 Module Regulates Creeping Bentgrass Thermotolerance by Modulating Auxin Biosynthesis and Signalling Pathway.Plant biotechnology journal · 2026Article
- CUL3Science advances · 2026Article
- Comparing hormone dynamics in cereal crops via transient expression of hormone sensors.Plant & cell physiology · 2025Article
- Threshold-dependent negative autoregulation of PIF4 gene expression optimizes growth and fitness in Arabidopsis.PLoS genetics · 2025Article
- Canalization of flower production across thermal environments requires Florigen and CLAVATA signaling.Current biology : CB · 2025Article
- Modulation of warm temperature-sensitive growth using a phytochrome B dark reversion variant, phyB[G515E], in Arabidopsis and rice.Journal of advanced research · 2024Article
- Nutrient levels control root growth responses to high ambient temperature in plants.Nature communications · 2024Article
- A warm temperature-released negative feedback loop fine-tunes PIF4-mediated thermomorphogenesis in Arabidopsis.Plant communications · 2024Article
- Assessing Temperature Responses in Roots.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Genome-Wide Characterization ofPlants (Basel, Switzerland) · 2023Article
- PHYTOCHROME-INTERACTING FACTOR 4/HEMERA-mediated thermosensory growth requires the Mediator subunit MED14.Plant physiology · 2022Article
- PIFs- and COP1-HY5-mediated temperature signaling in higher plants.Stress biology · 2022Review
- Plant AFC2 kinase desensitizes thermomorphogenesis through modulation of alternative splicing.iScience · 2022Article
- Review
- PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- PIF4 and PIF4-Interacting Proteins: At the Nexus of Plant Light, Temperature and Hormone Signal Integrations.International journal of molecular sciences · 2021Review
- Spatial regulation of thermomorphogenesis by HY5 and PIF4 in Arabidopsis.Nature communications · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Plant growth and development are acutely sensitive to high ambient temperature caused in part due to climate change. However, the mechanism of high ambient temperature signaling is not well defined. Here, we show that HECATEs (HEC1 and HEC2), two helix-loop-helix transcription factors, inhibit thermomorphogenesis. While the expression of HEC1 and HEC2 is increased and HEC2 protein is stabilized at high ambient temperature, hec1hec2 double mutant showed exaggerated thermomorphogenesis. Analyses of the four PHYTOCHROME INTERACTING FACTOR (PIF1, PIF3, PIF4 and PIF5) mutants and overexpression lines showed that they all contribute to promote thermomorphogenesis. Furthermore, genetic analysis showed that pifQ is epistatic to hec1hec2. HECs and PIFs oppositely control the expression of many genes in response to high ambient temperature. PIFs activate the expression of HECs in response to high ambient temperature. HEC2 in turn interacts with PIF4 both in yeast and in vivo. In the absence of HECs, PIF4 binding to its own promoter as well as the target gene promoters was enhanced, indicating that HECs control PIF4 activity via heterodimerization. Overall, these data suggest that PIF4-HEC forms an autoregulatory composite negative feedback loop that controls growth genes to modulate thermomorphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.