Evidence map›Paper›PMID 34061587›Full record

ArticleInfection and immunity2021

TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria.

Yash Pandya, Alexander Marta, André Barateiro, Carla Letícia Bandeira, Jamille Gregório Dombrowski, João Costa, Cláudio Romero Farias Marinho, Carlos Penha-Gonçalves

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Homeostasis Maintenance inFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yash PandyaInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Alexander MartaInstituto Gulbenkian de Ciência, Oeiras, Portugal.
André BarateiroDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, São Paulo, São Paulo, Brazil.
Carla Letícia BandeiraDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, São Paulo, São Paulo, Brazil.
Jamille Gregório DombrowskiDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, São Paulo, São Paulo, Brazil.
João CostaInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Cláudio Romero Farias MarinhoDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, São Paulo, São Paulo, Brazil.
Carlos Penha-GonçalvesInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Instituto Gulbenkian de Ciência · PTUniversidade de São Paulo · BR

Funding

REGULATION OF IL 12 PRODUCTION BY BETA 2 INTEGRINSZ01AI000809 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI KELSALL, BRIAN · 1997 to 2008
$902k
Intramural NIH HHS Z01 AI000809
6 · The paper itself

Abstract

Pregnancy-associated malaria is often associated with adverse pregnancy outcomes. Placental circulatory impairments are an intriguing and unsolved component of malaria pathophysiology. Here, we uncovered a Toll-like receptor 4 (TLR4)-TRIF-endothelin axis that controls trophoblast motility and is linked to fetal protection during

Indexed as

Signal TransductionBiomarkersBrazilEndothelinsFemaleHost-Pathogen InteractionsHumansMalariaPlacentaPregnancyPregnancy Complications, ParasiticPregnancy OutcomeToll-Like Receptor 4TrophoblastsBiomarkersEndothelinsTLR4 protein, humanToll-Like Receptor 4endothelinendothelin receptor Bplacental malariaToll-like receptor 4trophoblasts

Identifiers

PMID34061587
PMCPMC8281214
OpenAlexW3164225009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.