ArticleJournal of cachexia, sarcopenia and muscle2021
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases.
Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The impact of hepatic steatosis on outcomes of colorectal cancer patients with liver metastases: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Body Composition Is a Predictor for Postoperative Complications After Gastrectomy for Gastric Cancer: a Prospective Side Study of the LOGICA Trial.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Trial
- Beyond weight: a stigma-free, integrated approach to obesity in patients affected by cancer.Reviews in endocrine & metabolic disorders · 2026Review
- From steatosis to metastasis: microenvironmental reprogramming of the liver in metabolic dysfunction-associated steatotic liver disease.Clinical and molecular hepatology · 2026Review
- Subcutaneous adipose tissue outperforms muscle strength as an indicator of survival and quality of life in patients with cancer: a multicenter cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Myosteatosis mediates the link between specific dietary components and colorectal carcinogenesis: from PPLSS multi-center study.Asia Pacific journal of clinical nutrition · 2026Article
- The prognostic value of CT-measured body composition combined with radiomics in predicting the survival of patients with resectable colon cancer.La Radiologia medica · 2026Article
- Liver fat and clinical outcomes in individuals with stage I-III colon or rectal cancer.Journal of the National Cancer Institute · 2026Article
- Quality and Quantity? The Clinical Significance of Myosteatosis in Various Liver Diseases: A Narrative Review.Journal of clinical and translational hepatology · 2025Review
- Article
- Beyond the tumor: towards a cachexia-based host phenotype through body composition analysis in patients with resectable lung cancer.Translational lung cancer research · 2025Review
- Novel body component score predicts long-term survival in patients with stage I-III colorectal cancer following radical resection.Annals of gastroenterological surgery · 2025Article
- Association of the inflammatory microenvironment of obesity with pathological complete response in patients with breast cancer receiving neoadjuvant chemotherapy.Frontiers in endocrinology · 2025Article
- External validation of a deep learning model for automatic segmentation of skeletal muscle and adipose tissue on abdominal CT images.The British journal of radiology · 2024Article
- Cancer cachexia: multilevel metabolic dysfunction.Nature metabolism · 2024Review
- Inflammation-associated intramyocellular lipid alterations in human pancreatic cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2024Article
- Combined impact of myosteatosis and liver steatosis on prognosis in stage I-III colorectal cancer patients.Journal of cachexia, sarcopenia and muscle · 2023Article
- Prognostic Impact of Ectopic Fat Deposition within Psoas Muscle in Stage IV Gastric Cancer Patients Undergoing Systemic Chemotherapy.Journal of Cancer · 2022Article
- Imaging based body composition profiling and outcomes after oncologic liver surgery.Frontiers in oncology · 2022Review
- Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases.Journal of cachexia, sarcopenia and muscle · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyosteatosis has been associated with shorter overall survival in cancer patients. The increase in ectopic fat might not be limited to skeletal muscle only and might also extend to other sites such as the liver, resulting in non-alcoholic fatty liver disease (NAFLD). In this study, we assessed the relationship between myosteatosis and NAFLD and their association with overall survival in patients with colorectal liver metastases undergoing partial hepatectomy.
methodsPatients were selected from a prospective cohort of 289 consecutive patients with colorectal liver metastases. All patients with a preoperative computed tomography (CT)-scan and liver biopsy obtained during surgery were included. If available a second pre-operative CT scan was used to calculate changes in body composition over time. Muscle radiation attenuation was defined as the average Hounsfield units on CT of all muscle tissue at the L3 level. Liver biopsies were graded by a liver pathologist using the steatosis, activity, and fibrosis scoring system for NAFLD.
resultsTwo-hundred and eighteen patients had an available liver biopsy of which 131 patients had two available pre-operative CT scans with an average time interval of 3.2 months. One-hundred and thirty-five (62%) biopsies were classified as NAFLD. In multivariable Cox-regression analysis, NAFLD [hazard ratio (HR): 1.8, 95%-confidence interval (CI) 1.0-3.0, P = 0.037], increase in myosteatosis (HR 1.8, 95%-CI 1.1-2.9, P = 0.018), and skeletal muscle loss (HR 1.7, 95%-CI 1.0-2.9, P = 0.035) were independently associated with shorter overall survival while high visceral adipose tissue fat content was associated with longer overall survival (HR: 0.7, 95%-CI 0.5-0.9, P = 0.014).
conclusionsEctopic fat content of liver as well as skeletal muscle tissue is independently associated with shorter overall survival in patients with colorectal liver metastases, while increased visceral adipose tissue fat content is associated with longer overall survival.
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