Evidence map›Paper›PMID 34061327›Full record

ArticleMolecular biology reports2021

The correlation of estrogen receptor 1 and progesterone receptor genes polymorphisms with recurrent pregnancy loss in a cohort of Egyptian women.

Miral M Refeat, Taghreed Shalabi, Hala T El-Bassyouni, Mai Shaker

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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Miral M RefeatHuman Genetics and Genome Research Division, Medical Molecular Genetics Department, National Research Centre, Cairo, Egypt. mira_refeat@yahoo.com.ORCID http://orcid.org/0000-0002-0953-1452
Taghreed ShalabiHuman Genetics and Genome Research Division, Prenatal and Fetal Medicine Department, National Research Centre, Cairo, Egypt.ORCID http://orcid.org/0000-0001-6212-7021
Hala T El-BassyouniHuman Genetics and Genome Research Division, Clinical Genetics Department, National Research Centre, Cairo, Egypt.ORCID http://orcid.org/0000-0001-9825-1219
Mai ShakerHuman Genetics and Genome Research Division, Prenatal and Fetal Medicine Department, National Research Centre, Cairo, Egypt.ORCID http://orcid.org/0000-0002-4486-7234
National Research Centre · EGMedical Genetics Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) represents one of the pregnancy complications affecting 1-3% of women. Sex hormones, progesterone and estrogen play a critical role in the maintenance of pregnancy; they are mediated by estrogen receptor 1 (ESR1) and progesterone receptor (PR) genes respectively. Polymorphisms of (ESR1) and (PR) genes are linked to RPL. We aimed to explore the association of single nucleotide polymorphisms (SNPs) of (ESR1) gene and (PR) gene with RPL in a cohort of Egyptian population (50 infertile Egyptian women who experienced RPL and 50 healthy women), using polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) of (ESR1) gene and DNA sequencing of exons 1 and 5 of (PR) gene. Genotyping of ESR1 gene SNP's: (rs2234693) and (rs9340799) revealed higher significance in cases compared to controls of p value (p = 0.006 and p = 0.001) respectively. However, the frequencies of the two variants in (PG) gene; S344T (rs3740753) (p = 0.0001) and H770H (rs1042839) (p = 0.001) were significantly higher in women compared to the healthy control women. New polymorphism P352Q was observed in 2% of cases (p = 0.0001). There was a significant association of SNP's of ESR1 and PR genes with recurrent pregnancy loss RPL. Further demographics studies should be carried on a larger number of women at risk of recurrent implantation to elucidate this SNP's association and its role in RPL women.

Indexed as

Polymorphism, Single NucleotideAbortion, HabitualAdolescentAdultAllelesCase-Control StudiesCohort StudiesEgyptEstrogen Receptor alphaExonsFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansPolymorphism, Restriction Fragment LengthESR1 protein, humanEstrogen Receptor alphaReceptors, ProgesteroneDNA sequencingEstrogen receptor 1 genePCR–RFLPPolymorphismsProgesterone receptor geneRecurrent pregnancy loss

Identifiers

PMID34061327
OpenAlexW3164153512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.